Receptor Tyrosine Kinase Like Orphan Receptor 2 (ROR2)

NTRKR2; BDB; BDB1; Neurotrophic tyrosine kinase, receptor-related 2

SPN	S507
HGNC	10257
MGI	1347521
RGD	1305275
UniProt	Q01974

receptor tyrosine kinase-like orphan receptor 2) is a receptor protein tyrosine kinase and type I transmembrane protein that belongs to the ROR subfamily of cell surface receptors.

The protein may be involved in the early formation of the chondrocytes and may be required for cartilage and growth plate development. Mutations in this gene can cause brachydactyly type B, a skeletal disorder characterized by hypoplasia/aplasia of distal phalanges and nails. In addition, mutations in this gene can cause the autosomal recessive form of Robinow syndrome, which is characterized by skeletal dysplasia with generalized limb bone shortening, segmental defects of the spine, brachydactyly, and a dysmorphic facial appearance.

Reference

"A novel family of cell surface receptors with tyrosine kinase-like domain."
J. Biol. Chem. 267:26181-26190(1992) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"Dominant mutations in ROR2, encoding an orphan receptor tyrosine kinase, cause brachydactyly type B."
Nat. Genet. 24:275-278(2000) [PubMed] [Europe PMC] [Abstract]

"Distinct mutations in the receptor tyrosine kinase gene ROR2 cause brachydactyly type B."
Am. J. Hum. Genet. 67:822-831(2000) [PubMed] [Europe PMC] [Abstract]

"O-sulfonation of serine and threonine: mass spectrometric detection and characterization of a new posttranslational modification in diverse proteins throughout the eukaryotes."
Mol. Cell. Proteomics 3:429-440(2004) [PubMed] [Europe PMC] [Abstract]

"Homodimerization of Ror2 tyrosine kinase receptor induces 14-3-3(beta) phosphorylation and promotes osteoblast differentiation and bone formation."
Mol. Endocrinol. 21:3050-3061(2007) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2."
Nat. Genet. 25:419-422(2000) [PubMed] [Europe PMC] [Abstract]

"Mutation of the gene encoding the ROR2 tyrosine kinase causes autosomal recessive Robinow syndrome."
Nat. Genet. 25:423-426(2000) [PubMed] [Europe PMC] [Abstract]

Erratum
Nat. Genet. 26:383-383(2000) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]