C-Ros Oncogene 1, Receptor Tyrosine Kinase (ROS1)

MCF3; ROS; c-Ros-1; v-Ros Avian UR2 Sarcoma Virus Oncogene Homolog 1; Proto-oncogene tyrosine-protein kinase ROS; Receptor tyrosine kinase c-ros oncogene 1

SPN	S506
HGNC	10261
MGI	97999
RGD	3591
UniProt	P08922

This proto-oncogene, highly-expressed in a variety of tumor cell lines, belongs to the sevenless subfamily of tyrosine kinase insulin receptor genes. C-Ros Oncogene 1 is a type I integral membrane protein with tyrosine kinase activity. The protein may function as a growth or differentiation factor receptor.ROS1 encodes a protein tyrosine kinase with a potential transmembrane domain. It arose from the human ROS1 gene by a rearrangement introduced during gene transfer, which deleted the putative extracellular domain of ROS1, leaving potential transmembrane and intracellular protein tyrosine kinase domains intact.It contains an intracellular domain typical of tyrosine protein kinases, a transmembrane domain, a very large extracellular domain that contains 31 potential N-linked glycosylation sites, and a putative N-terminal signal peptide.

Reference

"Characterization of ROS1 cDNA from a human glioblastoma cell line."
Proc. Natl. Acad. Sci. U.S.A. 87:4799-4803(1990) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"Human c-ros-1 gene homologous to the v-ros sequence of UR2 sarcoma virus encodes for a transmembrane receptorlike molecule."
Mol. Cell. Biol. 6:3000-3004(1986) [PubMed] [Europe PMC] [Abstract]

"Characterization of an activated human ros gene."
Mol. Cell. Biol. 6:3109-3116(1986) [PubMed] [Europe PMC] [Abstract]

"Analysis of oncogene expression in primary human gliomas: evidence for increased expression of the ros oncogene."
Cancer Genet. Cytogenet. 72:130-136(1994) [PubMed] [Europe PMC] [Abstract]

"Vav3 mediates receptor protein tyrosine kinase signaling, regulates GTPase activity, modulates cell morphology, and induces cell transformation."
Mol. Cell. Biol. 20:9212-9224(2000) [PubMed] [Europe PMC] [Abstract]

"Fusion of FIG to the receptor tyrosine kinase ROS in a glioblastoma with an interstitial del(6)(q21q21)."
Genes Chromosomes Cancer 37:58-71(2003) [PubMed] [Europe PMC] [Abstract]

"Oncogenic targeting of an activated tyrosine kinase to the Golgi apparatus in a glioblastoma."
Proc. Natl. Acad. Sci. U.S.A. 100:916-921(2003) [PubMed] [Europe PMC] [Abstract]

"ROS fusion tyrosine kinase activates a SH2 domain-containing phosphatase-2/phosphatidylinositol 3-kinase/mammalian target of rapamycin signaling axis to form glioblastoma in mice."
Cancer Res. 66:7473-7481(2006) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]