Spleen Tyrosine Kinase (SYK)

p72-Syk; Spleen tyrosine kinase

SPN	S504
HGNC	11491
MGI	99515
PubMed	17182546
RGD	3796
UniProt	P43405
Wiki	SYK

SYKis a member of the Syk family of tyrosine kinases. While Syk and Zap-70 are primarily expressed in hematopoietic tissues, there is expression of Syk in a variety of tissues. Within B and T cells respectively, Syk and Zap-70 transmit signals from the B-Cell receptor and T-Cell receptor. Syk plays a similar role in transmitting signals from a variety of cell surface receptors including CD74, Fc Receptor, and integrins. The role of Syk in epithelial malignancies is controversial. Several authors have suggested that abnormal Syk function facilitates transformation in Nasopharyngeal carcinoma and head and neck cancer while other authors have suggested a tumor suppressor role in breast and gastric cancer.

Reference

"Cloning of the cDNA for the deleted syk kinase homologous to ZAP-70 from human basophilic leukemia cell line (KU812)."
Biochem. Biophys. Res. Commun. 200:28-34(1994) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of human Syk. A B cell protein-tyrosine kinase associated with the surface immunoglobulin M-B cell receptor complex."
J. Biol. Chem. 269:12310-12319(1994) [PubMed] [Europe PMC] [Abstract]

"DNA sequence and analysis of human chromosome 9."
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning of the human homologue to the pig protein-tyrosine kinase syk."
Immunogenetics 39:359-362(1994) [PubMed] [Europe PMC] [Abstract]

"Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases."
Immunity 2:155-166(1995) [PubMed] [Europe PMC] [Abstract]

"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product."
Immunity 5:591-604(1996) [PubMed] [Europe PMC] [Abstract]

"Phospholipase C-gamma1 interacts with conserved phosphotyrosyl residues in the linker region of Syk and is a substrate for Syk."
Mol. Cell. Biol. 16:1305-1315(1996) [PubMed] [Europe PMC] [Abstract]

"Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk tyrosine kinases."
J. Biol. Chem. 273:8867-8874(1998) [PubMed] [Europe PMC] [Abstract]

"Cbl-mediated negative regulation of the Syk tyrosine kinase. A critical role for Cbl phosphotyrosine-binding domain binding to Syk phosphotyrosine 323."
J. Biol. Chem. 273:35273-35281(1998) [PubMed] [Europe PMC] [Abstract]

"Dephosphorylation of ZAP-70 and inhibition of T cell activation by activated SHP1."
Eur. J. Immunol. 29:2539-2550(1999) [PubMed] [Europe PMC] [Abstract]

"SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling."
Proc. Natl. Acad. Sci. U.S.A. 96:9775-9780(1999) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and characterization of SPAP1, an inhibitory receptor."
Biochem. Biophys. Res. Commun. 280:768-775(2001) [PubMed] [Europe PMC] [Abstract]

"BLNK: molecular scaffolding through 'cis'-mediated organization of signaling proteins."
EMBO J. 21:6461-6472(2002) [PubMed] [Europe PMC] [Abstract]

"ITAM-based interaction of ERM proteins with Syk mediates signaling by the leukocyte adhesion receptor PSGL-1."
Immunity 17:401-412(2002) [PubMed] [Europe PMC] [Abstract]

"Coordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeleton."
J. Cell Biol. 157:265-275(2002) [PubMed] [Europe PMC] [Abstract]

"Association of the Src homology 2 domain-containing leukocyte phosphoprotein of 76 kD (SLP-76) with the p85 subunit of phosphoinositide 3-kinase."
FEBS Lett. 575:35-40(2004) [PubMed] [Europe PMC] [Abstract]

"The kinase Syk as an adaptor controlling sustained calcium signalling and B-cell development."
EMBO J. 27:1333-1344(2008) [PubMed] [Europe PMC] [Abstract]

"Molecular mechanism of the Syk activation switch."
J. Biol. Chem. 283:32650-32659(2008) [PubMed] [Europe PMC] [Abstract]

"Phosphoproteome of resting human platelets."
J. Proteome Res. 7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"CLEC-2 activates Syk through dimerization."
Blood 115:2947-2955(2010) [PubMed] [Europe PMC] [Abstract]

"Functional interaction between the ubiquitin-specific protease 25 and the SYK tyrosine kinase."
Exp. Cell Res. 316:667-675(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Complex phosphorylation dynamics control the composition of the Syk interactome in B cells."
Eur. J. Immunol. 41:1550-1562(2011) [PubMed] [Europe PMC] [Abstract]

"The protein-tyrosine kinase Syk interacts with the C-terminal region of tensin2."
Biochim. Biophys. Acta 1823:199-205(2012) [PubMed] [Europe PMC] [Abstract]

"Germinal centre protein HGAL promotes lymphoid hyperplasia and amyloidosis via BCR-mediated Syk activation."
Nat. Commun. 4:1338-1338(2013) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the C-terminal SH2 domain of the human tyrosine kinase Syk complexed with a phosphotyrosine pentapeptide."
Structure 3:1061-1073(1995) [PubMed] [Europe PMC] [Abstract]

"Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide."
J. Mol. Biol. 281:523-537(1998) [PubMed] [Europe PMC] [Abstract]