Rho GDP Dissociation Inhibitor Alpha (ARHGDIa)
GDIA1; RHOGDI; RHOGDI-1
- Aplysia Ras-related homologs (ARHs), also called Rho genes, belong to the RAS gene superfamily encoding small guanine nucleotide exchange (GTP/GDP) factors. The ARH proteins may be kept in the inactive, GDP-bound state by interaction with GDP dissociation inhibitors, such as ARHGDIA.
- ARHGDIA corresponded to a protein in the keratinocyte 2-dimensional-gel protein database known as IEF (isoelectric focusing) 8118. By 2-dimensional gel electrophoresis, the predicted 204-amino acid protein had a pI of 4.74 and migrated at 29 kD. The amino acid sequences of human and bovine ARHGDIA are 97% identical. Northern blot analysis revealed that ARHGDIA was expressed in all cell lines and tissues tested.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Hu01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Hu01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Hu01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Hu01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Hu01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Mu01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Mu01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Mu01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Mu01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Mu01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Ra01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Ra01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Ra01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Ra01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Ra01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Ca01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Ca01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Ca01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Ca01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Ca01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Po01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Po01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Po01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Po01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Po01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Bo01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Bo01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Bo01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Bo01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Bo01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Rb01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Rb01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Rb01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Rb01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Rb01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS455Mo01 | Recombinant Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS455Mo01 | Monoclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IP. |
| PAS455Mo01 | Polyclonal Antibody to Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS455Mo01 | CLIA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | CLIA assay for Antigen Detection |
| ELS455Mo01 | ELISA Kit for Rho GDP Dissociation Inhibitor Alpha (ARHGDIa) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of two human Rho GDP dissociation inhibitor proteins whose overexpression leads to disruption of the actin cytoskeleton."
Exp. Cell Res. 209:165-174(1993) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
, Submitted (MAY-2006) to UniProtKB
, Submitted (DEC-2008) to UniProtKB
"Regulation of the human neutrophil NADPH oxidase by rho-related G-proteins."
Biochemistry 32:5711-5717(1993) [PubMed] [Europe PMC] [Abstract]
"Substrate and functional diversity of lysine acetylation revealed by a proteomics survey."
Mol. Cell 23:607-618(2006) [PubMed] [Europe PMC] [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
"The Fer tyrosine kinase regulates interactions of Rho GDP-Dissociation Inhibitor alpha with the small GTPase Rac."
BMC Biochem. 11:48-48(2010) [PubMed] [Europe PMC] [Abstract]
"Gankyrin plays an essential role in Ras-induced tumorigenesis through regulation of the RhoA/ROCK pathway in mammalian cells."
J. Clin. Invest. 120:2829-2841(2010) [PubMed] [Europe PMC] [Abstract]
"Regulation of Rho GTPase crosstalk, degradation and activity by RhoGDI1."
Nat. Cell Biol. 12:477-483(2010) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"A modulator of rho family G proteins, rhoGDI, binds these G proteins via an immunoglobulin-like domain and a flexible N-terminal arm."
Structure 5:623-633(1997) [PubMed] [Europe PMC] [Abstract]
"ARHGDIA: a novel gene implicated in nephrotic syndrome."
J. Med. Genet. 50:330-338(2013) [PubMed] [Europe PMC] [Abstract]