Excitatory Amino Acid Transporter 1 (EAAT1)

SLC1A3; EA6; GLAST1; Sodium-dependent glutamate/aspartate transporter 1; Solute Carrier 1 Member 3,Glial High Affinity Glutamate Transporter; GLutamate Aspartate Transporter

SPN	S447
HGNC	10941
MGI	99917
PubMed	17221839
RGD	3698
UniProt	P43003
Wiki	SLC1A3

Glutamate and aspartate are excitatory neurotransmitters that have been implicated in a number of pathologic states of the nervous system. Accumulation of extracellular excitatory amino acids can be cytotoxic and may also lower the seizure threshold in epilepsy. EAAT1 (SLC1A3) is a member of a family of high-affinity sodium-dependent transporter molecules that regulate neurotransmitter concentrations at the excitatory glutamatergic synapses of the mammalian central nervous system. The cDNA encoded a deduced protein that was 95% homologous to a previously reported rabbit glutamate/aspartate transporter. The highest expression was found in the substantia nigra, red nucleus, and hippocampus, and in cerebral cortical layers

Reference

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