Home
›
Cationic Amino Acid Transporter 1 (CAT1)
Cationic Amino Acid Transporter 1 (CAT1)
SLC7A1; HCAT1; ATRC1; ERR; Solute Carrier Family 7 Member 1,Cationic Amino Acid Transporter,y+; Ecotropic Retroviral Receptor; High Affinity Cationic Amino Acid Transporter 1
Susceptibility to murine ecotropic retroviruses is attributed to the binding of the virus envelope to the membrane receptor encoded by the Rec1 gene. HCAT1 was identified as the principal transporter of the cationic amino acids, arginine, lysine, and ornithine in mouse cells. the Rec1 gene mapped to mouse chromosome 5 by analysis of murine-hamster somatic cell hybrids. Using a human cDNA obtained by homology to Rec1, Albritton et al. (1992) determined the location of the human cationic amino acid transporter by somatic cell genetics, in situ hybridization, and RFLP linkage analysis. The studies indicated that ATRC1 is located at 13q12-q14, closely linked to ATP1AL1. The CEPH consortium linkage map of chromosome 13 published by Bowcock et al. (1993) showed ATRC1 to be distal to ATP1AL1.
Organism species: Homo sapiens (Human)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Mus musculus (Mouse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
PS396Mu01
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Chicken (Gallus)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Cavia (Guinea pig )
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Organism species: Pan-species (General)
PRODUCT TYPE
CATALOG NO.
PRODUCT NAME
APPLICATIONS
Proteins
NONE
Recombinant Cationic Amino Acid Transporter 1 (CAT1) Positive Control; Immunogen; SDS-PAGE; WB.
NONE
Native Cationic Amino Acid Transporter 1 (CAT1) Bioactivity
Antibodies
NONE
Monoclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IP.
NONE
Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) WB; IHC; ICC; IF.
NONE
Biotin Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) ELISA(Det);IC; IH; IH(P); WB
NONE
APC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) IHC, WB
NONE
HRP Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Simple Western; WB
NONE
PE Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry
NONE
FITC Linked-Polyclonal Antibody to Cationic Amino Acid Transporter 1 (CAT1) Flow Cytometry;ICC/IF
Assay Kits
NONE
ELISA Kit for Cationic Amino Acid Transporter 1 (CAT1) Enzyme-linked immunosorbent assay for Antigen Detection
NONE
CLIA kit for Cationic Amino Acid Transporter 1 (CAT1) CLIA assay for Antigen Detection
Reference
"Molecular cloning and characterization of a novel human gene homologous to the murine ecotropic retroviral receptor." Virology 185:10-17(1991) [PubMed ] [Europe PMC ] [Abstract ]
"The human cationic amino acid transporter (ATRC1): physical and genetic mapping to 13q12-q14." Genomics 12:430-434(1992) [PubMed ] [Europe PMC ] [Abstract ]
"Identification of three cationic amino acid transporters in placental trophoblast: cloning, expression, and characterization of hCAT-1." J. Membr. Biol. 171:55-62(1999) [PubMed ] [Europe PMC ] [Abstract ]
"The DNA sequence and analysis of human chromosome 13." Nature 428:522-528(2004) [PubMed ] [Europe PMC ] [Abstract ]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." Genome Res. 14:2121-2127(2004) [PubMed ] [Europe PMC ] [Abstract ]