Hydrogen Ion/Peptide Transporter 2 (HPEPT2)

SLC15A2; PEPT2; Solute Carrier Family 15 Member 2,H+/Peptide Transporter; Oligopeptide transporter, kidney isoform; Kidney H(+)/peptide cotransporter

SPN	S371
HGNC	10921
MGI	1890457
PubMed	21796140
RGD	61972
UniProt	Q16348
Wiki	SLC15A2

This transporter, SLC15A2, belongs to the same gene family as SLC15A1, the proton-coupled peptide transporter found in the small intestine.The SLC15A2 cDNA encodes a predicted 729-amino acid protein that contains 12 transmembrane domains and a long hydrophilic segment between transmembrane domains 9 and 10.

The amino acid sequence of SLC15A2 shows 50% identity and 70% similarity with that of SLC15A1. Functional expression of the SLC15A2 cDNA in HeLa cells resulted in the induction of a proton-dependent transport system that was able to transport dipeptides, tripeptides, and beta-lactam antibiotics; free amino acids were not accepted as substrates. RT-PCR showed that SLC15A2 is expressed in kidney but not in intestine.

Reference

"Molecular cloning of PEPT 2, a new member of the H+/peptide cotransporter family, from human kidney."
Biochim. Biophys. Acta 1235:461-466(1995) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]