Gibbon Ape Leukemia Virus Receptor 1 (GLVR1)

SLC20A1; PIT1; Glvr-1; PiT-1; Sodium-Dependent Phosphate Transporter 1; Solute Carrier Family 20 Member 1; Leukemia virus receptor 1 homolog; Phosphate transporter 1

SPN	S363
HGNC	10946
MGI	108392
PubMed	21796222
RGD	621079
UniProt	Q8WUM9
Wiki	SLC20A1

Retrovirus receptors allow infection of human and murine cells by various retroviruses. The receptors that have been identified at the molecular level include CD4 for human immunodeficiency virus, Rec1 for murine ecotropic virus, and GLVR1 for gibbon ape leukemia virus. These 3 proteins show no homology to one another at the DNA or protein level. GLVR1 is a sodium-dependent phosphate symporter.

By expression in Xenopus oocytes and in mammalian cells, Kavanaugh et al. (1994) determined that GLVR1 is a sodium-dependent phosphate symporter. Voltage-clamp analysis indicated net cation influx, suggesting that phosphate is transported with excess sodium ions.

Reference

"Characterization of a human gene conferring sensitivity to infection by gibbon ape leukemia virus."
Cell Growth Differ. 1:119-127(1990) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human Glvr-1 phosphate transporter/retrovirus receptor gene and promoter region."
Gene 226:25-33(1999) [PubMed] [Europe PMC] [Abstract]

"Feline leukemia virus subgroup B uses the same cell surface receptor as gibbon ape leukemia virus."
J. Virol. 66:1219-1222(1992) [PubMed] [Europe PMC] [Abstract]

"GLVR1, a receptor for gibbon ape leukemia virus, is homologous to a phosphate permease of Neurospora crassa and is expressed at high levels in the brain and thymus."
J. Virol. 66:1635-1640(1992) [PubMed] [Europe PMC] [Abstract]

"Definition of a domain of GLVR1 which is necessary for infection by gibbon ape leukemia virus and which is highly polymorphic between species."
J. Virol. 67:6733-6736(1993) [PubMed] [Europe PMC] [Abstract]

"The cellular receptor for gibbon ape leukemia virus is a novel high affinity sodium-dependent phosphate transporter."
J. Biol. Chem. 269:25426-25431(1994) [PubMed] [Europe PMC] [Abstract]

"A family of retroviruses that utilize related phosphate transporters for cell entry."
J. Virol. 68:8270-8276(1994) [PubMed] [Europe PMC] [Abstract]

"Cell-surface receptors for gibbon ape leukemia virus and amphotropic murine retrovirus are inducible sodium-dependent phosphate symporters."
Proc. Natl. Acad. Sci. U.S.A. 91:7071-7075(1994) [PubMed] [Europe PMC] [Abstract]

"Phosphate regulation of vascular smooth muscle cell calcification."
Circ. Res. 87:E10-E17(2000) [PubMed] [Europe PMC] [Abstract]

"Reassessing the role of region A in Pit1-mediated viral entry."
J. Virol. 76:7683-7693(2002) [PubMed] [Europe PMC] [Abstract]

"Role of interleukin-8 in PiT-1 expression and CXCR1-mediated inorganic phosphate uptake in chondrocytes."
Arthritis Rheum. 52:144-154(2005) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]