Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1)
SLC25A12; ARALAR1; Solute Carrier Family 25 Member 12,Mitochondrial Carrier,Aralar; Calcium-binding mitochondrial carrier protein Aralar1
- The SLC25A12 gene encodes aralar, a protein that functions in the transport of aspartate from mitochondria to cytosol in exchange for glutamate. Aralar also plays a role in the transfer of cytosolic reducing equivalents into mitochondria as a member of the malate-aspartate NADH shuttle.
- The N-terminal portion of the predicted 678-amino acid aralar protein contains 3 canonical EF-hand calcium-binding domains and 2 imperfect EF-hand domains. The authors demonstrated that this half of the protein bound calcium in vitro. The C-terminal half of aralar shares 28 to 29% identity with proteins of the mitochondrial solute carrier family, including oxoglutarate/malate carrier, ADP/ATP translocase-2, UCP1, and tricarboxylate carrier.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Hu01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Hu01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Hu01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Hu01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Hu01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Mu01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Mu01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Mu01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Mu01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Mu01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Ra01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Ra01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Ra01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Ra01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Ra01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Ca01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Ca01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Ca01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Ca01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Ca01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Po01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Po01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Po01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Po01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Po01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Bo01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Bo01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Bo01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Bo01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Bo01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Rb01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Rb01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Rb01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Rb01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Rb01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS339Mo01 | Recombinant Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS339Mo01 | Monoclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IP. |
| PAS339Mo01 | Polyclonal Antibody to Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS339Mo01 | CLIA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | CLIA assay for Antigen Detection |
| ELS339Mo01 | ELISA Kit for Aspartate Glutamate Carrier Isoform 1, Mitochondrial (Agc1) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning of Aralar, a new member of the mitochondrial carrier superfamily that binds calcium and is present in human muscle and brain."
J. Biol. Chem. 273:23327-23334(1998) [PubMed] [Europe PMC] [Abstract]
"Citrin and aralar1 are Ca(2+)-stimulated aspartate/glutamate transporters in mitochondria."
EMBO J. 20:5060-5069(2001) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The gene mutated in adult-onset type II citrullinaemia encodes a putative mitochondrial carrier protein."
Nat. Genet. 22:159-163(1999) [PubMed] [Europe PMC] [Abstract]
"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
"AGC1 deficiency associated with global cerebral hypomyelination."
N. Engl. J. Med. 361:489-495(2009) [PubMed] [Europe PMC] [Abstract]
Erratum
N. Engl. J. Med. 361:731-731(2009)
"AGC1 deficiency causes infantile epilepsy, abnormal myelination, and reduced n-acetylaspartate."
JIMD Rep. 14:77-85(2014) [PubMed] [Europe PMC] [Abstract]