Solute Carrier Family 39, Member 4 (SLC39A4)
ZIP4; AEZ; Acrodermatitis Enteropathica,Zinc-Deficiency Type; Zinc Transporter Protein 4; Zinc transporter ZIP4; Zrt-and Irt-like protein 4
SLC39A4 gene as a candidate intestinal zinc-specific transporter within the susceptibility locus for the zinc-deficiency type of acrodermatitis enteropathica (AEZ) on 8q24.3. The gene is expressed as an mRNA of 2.5 kb in only a few tissues, i.e., kidney, colon, duodenum and jejunum. The duodenum and jejunum are crucial sites of zinc absorption. These transcripts encode proteins of 647 and 622 amino acids sharing the same C-terminal 583 residues. Computational analysis predicted that the larger protein has a cytoplasmic membrane location and a secondary structure characteristic of a ZIP protein, consisting of 8 transmembrane domains organized in 2 blocks of 3 and 5, respectively. These 2 blocks are separated by a variable intracytoplasmic metal-binding site.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Hu01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Hu01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Hu01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Hu01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Hu01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Mu01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Mu01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Mu01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Mu01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Mu01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Ra01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Ra01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Ra01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Ra01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Ra01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Ca01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Ca01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Ca01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Ca01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Ca01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Po01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Po01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Po01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Po01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Po01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Bo01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Bo01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Bo01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Bo01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Bo01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Rb01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Rb01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Rb01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Rb01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Rb01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS317Mo01 | Recombinant Solute Carrier Family 39, Member 4 (SLC39A4) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS317Mo01 | Monoclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IP. |
| PAS317Mo01 | Polyclonal Antibody to Solute Carrier Family 39, Member 4 (SLC39A4) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS317Mo01 | CLIA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | CLIA assay for Antigen Detection |
| ELS317Mo01 | ELISA Kit for Solute Carrier Family 39, Member 4 (SLC39A4) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Identification of SLC39A4, a gene involved in acrodermatitis enteropathica."
Nat. Genet. 31:239-240(2002) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence and analysis of human chromosome 8."
Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A novel member of a zinc transporter family is defective in acrodermatitis enteropathica."
Am. J. Hum. Genet. 71:66-73(2002) [PubMed] [Europe PMC] [Abstract]
"Zn2+-stimulated endocytosis of the mZIP4 zinc transporter regulates its location at the plasma membrane."
J. Biol. Chem. 279:4523-4530(2004) [PubMed] [Europe PMC] [Abstract]
"Novel SLC39A4 mutations in acrodermatitis enteropathica."
J. Invest. Dermatol. 120:963-966(2003) [PubMed] [Europe PMC] [Abstract]