Cell Adhesion Molecule 1 (CADM1)

BL2; IGSF4; IGSF4A; NECL2; RA175; ST17; SYNCAM; TSLC1; sTSLC-1; synCAM1; Tumor Suppressor In Lung Cancer 1; Immunoglobulin Superfamily,Member 4; Nectin-Like 2

SPN	S257
HGNC	5951
MGI	1889272
PubMed	22429880
RGD	1310999
UniProt	Q9BY67
Wiki	CADM1

Loss of genetic material at the cytogenetic level and loss of heterozygosity (LOH) are frequently observed in tumors. The 11q22-q24 region has deletions or LOH in a variety of tumor types. Replacement of the missing copy of chromosome 11 in the A549 adenocarcinoma cell line with a normal chromosome 11 reversed tumorigenicity in nude mice, suggesting the existence of a tumor suppressor gene. TSLC1 localized in perinuclear and plasma membranes.The predicted 442-amino acid protein contains a signal peptide and a transmembrane domain. IGSF4 shares 65% identity with neural cell adhesion molecule-1 (NCAM1) and NCAM2 within their Ig-like C2-type domains. Northern blot analysis revealed expression of a 4.4-kb transcript in all tissues tested except leukocytes.

Reference

"Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane."
Biochim. Biophys. Acta 1669:142-154(2005) [PubMed] [Europe PMC] [Abstract]

"CADM1 isoforms differentially regulate human mast cell survival and homotypic adhesion."
Cell. Mol. Life Sci. 69:2751-2764(2012) [PubMed] [Europe PMC] [Abstract]

"Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism."
Nat. Commun. 5:3650-3650(2014) [PubMed] [Europe PMC] [Abstract]

"Cloning of a secretory isoform of SgIGSF/TSLC-1."
Submitted (OCT-2002) to the EMBL/GenBank/DDBJ databases.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract].

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"TSLC1 is a tumor-suppressor gene in human non-small-cell lung cancer."
Nat. Genet. 27:427-430(2001) [PubMed] [Europe PMC] [Abstract]

"Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer."
Cancer Res. 62:5129-5133(2002) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor protein TSLC1 is involved in cell-cell adhesion."
J. Biol. Chem. 277:31014-31019(2002) [PubMed] [Europe PMC] [Abstract]

"The cytoplasmic domain is critical to the tumor suppressor activity of TSLC1 in non-small cell lung cancer."
Cancer Res. 63:7979-7985(2003) [PubMed] [Europe PMC] [Abstract]

"Promoter methylation of the TSLC1 gene in advanced lung tumors and various cancer cell lines."
Int. J. Cancer 107:53-59(2003) [PubMed] [Europe PMC] [Abstract]

"Expression of the TSLC1 adhesion molecule in pulmonary epithelium and its down-regulation in pulmonary adenocarcinoma other than bronchioloalveolar carcinoma."
Lab. Invest. 83:1175-1183(2003) [PubMed] [Europe PMC] [Abstract]

"Association of a lung tumor suppressor TSLC1 with MPP3, a human homologue of Drosophila tumor suppressor Dlg."
Oncogene 22:6160-6165(2003) [PubMed] [Europe PMC] [Abstract]

"Re-expression of TSLC1 in a non-small-cell lung cancer cell line induces apoptosis and inhibits tumor growth."
Oncogene 23:5632-5642(2004) [PubMed] [Europe PMC] [Abstract]

"The tumor suppressor TSLC1/NECL-2 triggers NK-cell and CD8+ T-cell responses through the cell-surface receptor CRTAM."
Blood 106:779-786(2005) [PubMed] [Europe PMC] [Abstract]

"Nectin-like protein 2 defines a subset of T-cell zone dendritic cells and is a ligand for class-I-restricted T-cell-associated molecule."
J. Biol. Chem. 280:21955-21964(2005) [PubMed] [Europe PMC] [Abstract]

"The spermatogenic Ig superfamily/synaptic cell adhesion molecule mast-cell adhesion molecule promotes interaction with nerves."
J. Immunol. 174:6934-6942(2005) [PubMed] [Europe PMC] [Abstract]

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

Ref.19"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B)."
J. Biol. Chem. 286:4511-4516(2011) [PubMed] [Europe PMC] [Abstract]