WAP Four Disulfide Core Domain Protein 5 (WFDC5)

WAP1; Putative protease inhibitor WAP1; p53-responsive gene 5 protein

SPN	S249
HGNC	20477
MGI	2384800
PubMed	23840300
RGD	1304986
UniProt	Q8TCV5
Wiki	WFDC5

WFDC5 encodes a member of the WAP-type four-disulfide core (WFDC) domain family. Most WFDC proteins contain only one WFDC domain, and this encoded protein contains two WFDC domains. The WFDC domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. The deduced 123-amino acid protein contains an N-terminal signal peptide, followed by 2 WAP domains. Each WAP domain contains 8 cysteines that form conserved disulfide bridges, and each WAP domain forms a proposed protease-binding loop and a beta sheet. The mature 99-amino acid WAP1 protein has a calculated molecular mass of 10.9 kD.

Reference

"A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein."
Biochem. J. 368:233-242(2002) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and comparative analysis of human chromosome 20."
Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Isolation of differentially expressed cDNAs from p53-dependent apoptotic cells: activation of the human homologue of the Drosophila peroxidasin gene."
Biochem. Biophys. Res. Commun. 261:864-869(1999) [PubMed] [Europe PMC] [Abstract]