Glycoprotein 2, Zymogen Granule Membrane (GP2)

ZAP75; Pancreatic Secretory Granule Membrane Major Glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2

SPN	S232
HGNC	4441
MGI	1914383
PubMed	21468225
RGD	621695
UniProt	P55259
Wiki	GP2_(gene

The enzyme and zymogen forms of digestive enzymes are stored in secretory zymogen granules (ZGs) in the exocrine pancreas. Since peptide hormones and cholinergic agents enhance release of ZG contents into the apical medium, ZGs constitute an important storage compartment in the regulated secretory pathway. The process of zymogen storage captures large quantities of cellular membranes destined for targeting to the apical plasma membrane.

Fukuoka et al. (1991) isolated dog cDNAs encoding GP2, a 75-kD protein that represents the major protein in ZG membranes. They found that GP2 is a GPI (glycosylphosphatidylinositol)-linked membrane protein released from the membrane of mature zymogen granules by an enzymatic mechanism.

Reference

"Sequence of the cDNA encoding human GP-2, the major membrane protein in the secretory granule of the exocrine pancreas."
Gene 171:311-312(1996) [PubMed] [Europe PMC] [Abstract]

"The sequence and analysis of duplication-rich human chromosome 16."
Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning and sequences of cDNAs encoding alpha (large) and beta (small) isoforms of human pancreatic zymogen granule membrane-associated protein GP2."
Biochim. Biophys. Acta 1491:376-380(2000) [PubMed] [Europe PMC] [Abstract]