Alpha-1-B-Glycoprotein (a1BG)

SPN	S231
HGNC	5
MGI	2152878
PubMed	23690342
RGD	69417
UniProt	P04217
Wiki	a1BG

Alpha-1B-glycoprotein is present in normal adult plasma at an average concentration of 22 mg/dl. Gahne et al. (1987) observed genetic polymorphism of A1B using one-dimensional horizontal polyacrylamide gel electrophoresis followed by Western blotting with specific antiserum. Three different phenotypes, designated 1-1, 1-2, and 2-2, were observed. Family data supported the hypothesis that the three phenotypes are determined by 2 codominant alleles at an autosomal locus.

In pigs the homologous locus is linked to malignant hyperthermia. Several other linkages in pigs and in horses suggest that human chromosomes 19, 6, and 1 are 'candidate chromosomes' for bearing the human A1B.

Reference

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"Amino acid sequence of human plasma alpha 1B-glycoprotein: homology to the immunoglobulin supergene family."
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