B-Cell CLL/Lymphoma 9 (Bcl9)

LGS; Protein legless homolog

SPN	S216
HGNC	1008
MGI	1924828
PubMed	18627596
UniProt	O00512
Wiki	BCL9

BCL9 is associated with B-cell acute lymphoblastic leukemia. It may be a target of translocation in B-cell malignancies with abnormalities of 1q21. Its function is unknown. The overexpression of BCL9 may be of pathogenic significance in B-cell malignancies.One allele showed novel sequences upstream of JH5 with no homology to either IGH or any other sequence in databases. Using a single-copy restriction fragment immediately 5-prime of JH5, PAC clones were isolated and mapped to 1q21 on normal metaphases by fluorescence in situ hybridization, confirming that this allele represented the translocation breakpoint. Sequence analysis of the 1q21 restriction fragment showed identity with an expressed sequenced tag, and this probe was therefore used to probe Northern blots.

Reference

"Molecular cloning of translocation t(1;14)(q21;q32) defines a novel gene (BCL9) at chromosome 1q21."
Blood 91:1873-1881(1998) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex."
Cell 109:47-60(2002) [PubMed] [Europe PMC] [Abstract]

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of a beta-catenin/BCL9/Tcf4 complex."
Mol. Cell 24:293-300(2006) [PubMed] [Europe PMC] [Abstract]

"Decoding of methylated histone H3 tail by the Pygo-BCL9 Wnt signaling complex."
Mol. Cell 30:507-518(2008) [PubMed] [Europe PMC] [Abstract]