Huntingtin Interacting Protein 2 (HIP2)
HYPG; LIG; UBE2K; Ubiquitin-Conjugating Enzyme E2K; Ubiquitin carrier protein; Ubiquitin-protein ligase
HIP2 belongs to the ubiquitin-conjugating enzyme family. It binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. This protein has been implicated in the degradation of huntingtin and suppression of apoptosis.
The 200-amino acid HIP2 protein sequence was identical to that of bovine ubiquitin-conjugating enzyme E2-25K. Assays of the interaction of HIP2 with huntingtin revealed that HIP2 binds selectively to a large region at the N terminus of huntingtin. This interaction is not influenced by the length of the huntingtin polyglutamine tract. Western blot analysis detected protein bands of 25, 28, and 45 kD; the 28-kD band appeared to be selective for tissues of the central nervous system.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Hu01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Hu01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Hu01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Hu01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Hu01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Mu01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Mu01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Mu01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Mu01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Mu01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Ra01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Ra01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Ra01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Ra01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Ra01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Ca01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Ca01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Ca01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Ca01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Ca01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Po01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Po01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Po01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Po01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Po01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Bo01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Bo01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Bo01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Bo01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Bo01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Rb01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Rb01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Rb01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Rb01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Rb01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS200Mo01 | Recombinant Huntingtin Interacting Protein 2 (HIP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS200Mo01 | Monoclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IP. |
| PAS200Mo01 | Polyclonal Antibody to Huntingtin Interacting Protein 2 (HIP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS200Mo01 | CLIA Kit for Huntingtin Interacting Protein 2 (HIP2) | CLIA assay for Antigen Detection |
| ELS200Mo01 | ELISA Kit for Huntingtin Interacting Protein 2 (HIP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
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