Regenerating Islet Derived Protein 3 Alpha (REG3a)

HIP; INGAP; PAP-H; PAP1; PBCGF; REG-III; REG3; Pancreatitis-Associated Protein; Hepatointestinal pancreatic protein; Human proislet peptide; Pancreatitis-associated protein 1

SPN	S176
HGNC	8601
MGI	109408
PubMed	22727489
RGD	3254
UniProt	Q06141
Wiki	REG3A

Regenerating islet-derived protein 3 alpha is a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The predicted protein had the same size as the rat protein and showed 71% amino acid identity, the 6 half-cysteines being in identical positions. As in the rat, the protein was expressed at very low levels in control tissues and overexpressed during the acute phase of pancreatitis in humans. The protein could be immunolocalized to the apical regions of acinar cells. The protein was also quantifiable in serum with an elevation of levels in pancreatitis, suggesting its possible use as a biologic marker of the disease.

Reference

"Cloning and tissue-specific expression of cDNAs for the human and mouse homologues of rat pancreatitis-associated protein (PAP)."
Biochim. Biophys. Acta 1172:184-186(1993) [PubMed] [Europe PMC] [Abstract]

"Human pancreatitis-associated protein. Messenger RNA cloning and expression in pancreatic diseases."
J. Clin. Invest. 90:2284-2291(1992) [PubMed] [Europe PMC] [Abstract]

"A novel gene (HIP) activated in human primary liver cancer."
Cancer Res. 52:5089-5095(1992) [PubMed] [Europe PMC] [Abstract]

"Molecular cloning, genomic organization, and chromosomal localization of the human pancreatitis-associated protein (PAP) gene."
Genomics 19:108-114(1994) [PubMed] [Europe PMC] [Abstract]

"Structural organization and chromosomal localization of a human gene (HIP/PAP) encoding a C-type lectin overexpressed in primary liver cancer."
Eur. J. Biochem. 224:29-38(1994) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation."
Biochem. J. 420:335-343(2009) [PubMed] [Europe PMC] [Abstract]

"Symbiotic bacteria direct expression of an intestinal bactericidal lectin."
Science 313:1126-1130(2006) [PubMed] [Europe PMC] [Abstract]

"The antimicrobial protein REG3A regulates keratinocyte proliferation and differentiation after skin injury."
Immunity 37:74-84(2012) [PubMed] [Europe PMC] [Abstract]

"Molecular basis for peptidoglycan recognition by a bactericidal lectin."
Proc. Natl. Acad. Sci. U.S.A. 107:7722-7727(2010) [PubMed] [Europe PMC] [Abstract]