Cell Division Cycle Protein 7 (CDC7)

CDC7L1; HsCDC7; Hsk1; huCDC7; Cell Division Cycle 7-Related Protein Kinase

SPN	S166
HGNC	1745
MGI	1309511
PubMed	23424178
RGD	1308351
UniProt	O00311
Wiki	CDC7

CDC7 is predominantly localized in the nucleus and is a cell division cycle protein with kinase activity. Although expression levels of the protein appear to be constant throughout the cell cycle, the protein kinase activity appears to increase during S phase. It has been suggested that the protein is essential for initiation of DNA replication and that it plays a role in regulating cell cycle progression. Overexpression of this gene product may be associated with neoplastic transformation for some tumors. Additional transcript sizes have been detected, suggesting the presence of alternative splicing.Cell division cycle 7 (CDC7) is a gene that codes for the protein Cdc7 kinase. The Cdc7 kinase is involved in regulation of the cell cycle at the point of chromosmal DNA replication.

Reference

"Human and Xenopus cDNAs encoding budding yeast Cdc7-related kinases: in vitro phosphorylation of MCM subunits by a putative human homologue of Cdc7."
EMBO J. 16:4340-4351(1997) [PubMed] [Europe PMC] [Abstract]

"A human homolog of the yeast CDC7 gene is overexpressed in some tumors and transformed cell lines."
Gene 211:133-140(1998) [PubMed] [Europe PMC] [Abstract]

"Identification and characterization of a human protein kinase related to budding yeast Cdc7p."
Proc. Natl. Acad. Sci. U.S.A. 94:14320-14325(1997) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells."
Mol. Cell. Biol. 19:5083-5095(1999) [PubMed] [Europe PMC] [Abstract]

"Drf1, a novel regulatory subunit for human Cdc7 kinase."
EMBO J. 21:3171-3181(2002) [PubMed] [Europe PMC] [Abstract]

"A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases."
J. Biol. Chem. 280:13062-13070(2005) [PubMed] [Europe PMC] [Abstract]

"Cdc7 is an active kinase in human cancer cells undergoing replication stress."
J. Biol. Chem. 282:208-215(2007) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"Large-scale proteomics analysis of the human kinome."
Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

"Patterns of somatic mutation in human cancer genomes."
Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]