Cell Division Cycle Protein 25 (CDC25)

CDC25A; CDC25A2; M-phase inducer phosphatase 1

SPN	S163
HGNC	1725
MGI	103198
PubMed	17568790
RGD	621498
UniProt	P30304
Wiki	CDC25A

cycle". Dual-specificity phosphatases are considered a sub-class of protein tyrosine phosphatases. Cdc25A in Checkpoints and Cancer CDC25A is specifically degraded in response to DNA damage resulting in cell cycle arrest; this degradation thus represents one axis of a DNA damage checkpoint, complementing induction of p53 and p21 in the inhibition of Cdks. CDC25A is considered an oncogene, as it can cooperate with oncogenic ras to transform rodent fibroblasts and it is overexpressed in tumours from a variety of tissues, including breast and head & neck tumours.

Reference

"Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins."
Cell 67:1181-1194(1991) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Alternative splicing in the regulatory region of the human phosphatases CDC25A and CDC25C."
Eur. J. Cell Biol. 79:810-815(2000) [PubMed] [Europe PMC] [Abstract]

"The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis."
Nature 410:842-847(2001) [PubMed] [Europe PMC] [Abstract]

"Dual mode of degradation of Cdc25 A phosphatase."
EMBO J. 21:4875-4884(2002) [PubMed] [Europe PMC] [Abstract]

"Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints."
Proc. Natl. Acad. Sci. U.S.A. 99:14795-14800(2002) [PubMed] [Europe PMC] [Abstract]

"Chk1 regulates the S phase checkpoint by coupling the physiological turnover and ionizing radiation-induced accelerated proteolysis of Cdc25A."
Cancer Cell 3:247-258(2003) [PubMed] [Europe PMC] [Abstract]

"SCFbeta-TRCP links Chk1 signaling to degradation of the Cdc25A protein phosphatase."
Genes Dev. 17:3062-3074(2003) [PubMed] [Europe PMC] [Abstract]

"Chk1 mediates S and G2 arrests through Cdc25A degradation in response to DNA-damaging agents."
J. Biol. Chem. 278:21767-21773(2003) [PubMed] [Europe PMC] [Abstract]

"Phosphorylation at serine 75 is required for UV-mediated degradation of human Cdc25A phosphatase at the S-phase checkpoint."
J. Biol. Chem. 278:29824-29829(2003) [PubMed] [Europe PMC] [Abstract]

"Chk1 kinase negatively regulates mitotic function of Cdc25A phosphatase through 14-3-3 binding."
Mol. Cell. Biol. 23:7488-7497(2003) [PubMed] [Europe PMC] [Abstract]

"The oncogenic serine/threonine kinase Pim-1 directly phosphorylates and activates the G2/M specific phosphatase Cdc25C."
Int. J. Biochem. Cell Biol. 38:430-443(2006) [PubMed] [Europe PMC] [Abstract]

"NEK11 regulates CDC25A degradation and the IR-induced G2/M checkpoint."
Nat. Cell Biol. 11:1247-1253(2009) [PubMed] [Europe PMC] [Abstract]

"NEK11: linking CHK1 and CDC25A in DNA damage checkpoint signaling."
Cell Cycle 9:450-455(2010) [PubMed] [Europe PMC] [Abstract]

"Ubiquitin hydrolase Dub3 promotes oncogenic transformation by stabilizing Cdc25A."
Nat. Cell Biol. 12:400-406(2010) [PubMed] [Europe PMC] [Abstract]

"Absence of polo-like kinase 3 in mice stabilizes Cdc25A after DNA damage but is not sufficient to produce tumors."
Mutat. Res. 714:1-10(2011) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the catalytic domain of the human cell cycle control phosphatase, Cdc25A."
Cell 93:617-625(1998) [PubMed] [Europe PMC] [Abstract]