Cell Division Cycle Protein 42 (CDC42)

CDC42Hs; G25K; G25K GTP-binding protein

SPN	S157
HGNC	1736
MGI	106211
PubMed	22719838
RGD	71043
UniProt	P60953
Wiki	CDC42

CDC42 is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression.

This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants.

Reference

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Submitted (JUN-1997) to the PDB data bank

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