Cyclin Dependent Kinase Inhibitor 2D (CDKN2D)

INK4D; p19; p19-INK4D; Cyclin-dependent kinase 4 inhibitor D

SPN	S142
HGNC	1790
MGI	105387
PubMed	22747700
UniProt	P55273
Wiki	CDKN2D

Cyclin-dependent kinase 4 inhibitor D is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression.

The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported.

Reference

"Molecular cloning, expression pattern, and chromosomal localization of human CDKN2D/INK4d, an inhibitor of cyclin D-dependent kinases."
Genomics 29:623-630(1995) [PubMed] [Europe PMC] [Abstract]

"Identification of human and mouse p19, a novel CDK4 and CDK6 inhibitor with homology to p16ink4."
Mol. Cell. Biol. 15:2682-2688(1995) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of p19INK4d, a p16-related inhibitor specific to CDK6 and CDK4."
Mol. Biol. Cell 7:57-70(1996) [PubMed] [Europe PMC] [Abstract]

"Mutation testing in melanoma families: INK4A, CDK4 and INK4D."
Br. J. Cancer 80:295-300(1999) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

"Active cdk6 complexes are predominantly nuclear and represent only a minority of the cdk6 in T cells."
Oncogene 16:603-611(1998) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16INK4a."
Nature 395:237-243(1998) [PubMed] [Europe PMC] [Abstract]

"Structure of human cyclin-dependent kinase inhibitor p19(INK4d): comparison to known ankyrin-repeat-containing structures and implications for the dysfunction of tumor suppressor p16(INK4a)."
Structure 6:1279-1290(1998) [PubMed] [Europe PMC] [Abstract]