Cyclin Dependent Kinase 2 Associated Protein 1 (CDK2AP1)

DOC1; DORC1; ST19; Doc-1; p12DOC-1; CDKAP1; Deleted in oral cancer 1; Putative oral cancer suppressor

SPN	S140
HGNC	14002
MGI	1202069
PubMed	20555355
RGD	1308664
UniProt	O14519
Wiki	CDK2AP1

Cyclin-dependent kinase 2-associated protein 1is a specific CDK2-associated protein, which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggested the regulatory role in DNA replication during S phase of the cell cycle. A similar gene in hamster was isolated from, and functions as a growth suppressor of normal keratinocytes.To investigate its possible role in esophageal carcinogenesis, they examined genetic alterations in expression levels of the gene in 13 esophageal carcinoma cell lines and 10 primary esophageal carcinomas.

Reference

"Isolation, mapping and mutation analysis of a human cDNA homologous to the doc-1 gene of the Chinese hamster, a candidate tumor suppressor for oral cancer."
Genes Chromosomes Cancer 20:204-207(1997) [PubMed] [Europe PMC] [Abstract]

"Cloning, mapping, expression, function, and mutation analyses of the human ortholog of the hamster putative tumor suppressor gene Doc-1."
J. Biol. Chem. 273:6704-6709(1998) [PubMed] [Europe PMC] [Abstract]

"The finished DNA sequence of human chromosome 12."
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Human cyclin-dependent kinase 2-associated protein 1 (CDK2AP1) is dimeric in its disulfide-reduced state, with natively disordered N-terminal region."
J. Biol. Chem. 287:16541-16549(2012) [PubMed] [Europe PMC] [Abstract]