Guanylate Binding Protein 6 (GBP6)

GTP-binding protein 6; Guanine nucleotide-binding protein 6

SPN	S138
HGNC	25395
MGI	97072
PubMed	21647175
UniProt	Q6ZN66

Guanylate-binding proteins, such as GBP6, are induced by interferon and hydrolyze GTP to both GDP and GMP.Olszewski et al. (2006) identified GBP6 within the GBP gene cluster on chromosome 1. The 634-amino acid GBP6 protein shares 74% identity with both GBP7 and GBP4. All GBPs, including GBP6, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases.

GBP6 lacks a C-terminal CaaX isoprenylation motif found in GBP1, GBP2, and GBP5 . EST database analysis indicated that GBP6 expression was limited to larynx, muscle, and tongue.Using RT-PCR, Tripal et al. (2007) detected expression of all GBPs except GBP6 and GBP7 in endothelial cells after stimulation with IFNG, TNF, or IL1B.

Reference

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Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]