Guanylate Binding Protein 2, Interferon Inducible (GBP2)
GTP-binding protein 2; Guanine nucleotide-binding protein 2
Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for the guanylate-binding proteins (GBPs). GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). The protein encoded by this gene is a GTPase that converts GTP to GDP and GMP.Olszewski et al. (2006) found that GBP2 shares 76% amino acid identity with GBP3, but only 54% and 57% identity with GBP6 and GBP7, respectively. All GBPs, including GBP2, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. EST database analysis indicated wide expression of GBP2 in human tissues.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Hu01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Hu01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Hu01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Hu01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Hu01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Mu01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Mu01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Mu01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Mu01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Mu01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Ra01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Ra01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Ra01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Ra01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Ra01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Ca01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Ca01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Ca01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Ca01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Ca01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Po01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Po01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Po01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Po01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Po01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Bo01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Bo01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Bo01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Bo01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Bo01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Rb01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Rb01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Rb01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Rb01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Rb01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS135Mo01 | Recombinant Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS135Mo01 | Monoclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IP. |
| PAS135Mo01 | Polyclonal Antibody to Guanylate Binding Protein 2, Interferon Inducible (GBP2) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS135Mo01 | CLIA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | CLIA assay for Antigen Detection |
| ELS135Mo01 | ELISA Kit for Guanylate Binding Protein 2, Interferon Inducible (GBP2) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP."
Mol. Cell. Biol. 11:4717-4725(1991) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"GTPase properties of the interferon-induced human guanylate-binding protein 2."
FEBS Lett. 390:69-72(1996) [PubMed] [Europe PMC] [Abstract]
"Unique features of different members of the human guanylate-binding protein family."
J. Interferon Cytokine Res. 27:44-52(2007) [PubMed] [Europe PMC] [Abstract]
"Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner."
PLoS ONE 5:E14246-E14246(2010) [PubMed] [Europe PMC] [Abstract]