Guanylate Binding Protein 1, Interferon Inducible (GBP1)

GTP-binding protein 1; Guanine nucleotide-binding protein 1

SPN	S134
HGNC	4182
MGI	102772
PubMed	23633952
RGD	621810
UniProt	P32455
Wiki	GBP1

Interferons are cytokines that have antiviral effects and inhibit tumor cell proliferation. They induce a large number of genes in their target cells, including those coding for guanylate-binding proteins (GBPs). GBPs, such as GBP1, are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP) and are distinguished from the GTP-binding proteins by the presence of 2 binding motifs rather than 3.

All GBPs, including GBP1, have a conserved N-terminal globular GTP-binding domain containing 2 consensus sequences and a third T(L/V)RD sequence not found in other GTPases. GBP1, GBP2, and GBP5 contain a C-terminal CaaX isoprenylation motif. EST database analysis showed wide expression of GBP1 in human tissues.

Reference

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