Receptor Interacting Serine Threonine Kinase 1 (RIPK1)

RIP; Receptor-Interacting Protein; Cell death protein RIP; Serine/threonine-protein kinase RIP

SPN	S131
HGNC	10019
MGI	108212
PubMed	22814620
RGD	1310158
UniProt	Q13546
Wiki	RIPK1

Two cell surface cytokine receptors, FAS and tumor necrosis factor (TNF) receptor, trigger apoptosis by natural ligands or specific agonist antibodies. Both receptors contain a conserved intracellular death domain. Using a yeast 2-hybrid screen with the cytoplasmic domain of FAS as bait, Stanger et al. (1995) isolated partial cDNAs encoding a receptor-interacting protein which they designated RIP. They used the partial cDNAs to isolate mouse cDNAs corresponding to the entire Rip coding region. Hsu et al. (1996) isolated a full-length human RIP cDNA. They reported that the predicted 671-amino acid RIP protein contains an N-terminal protein kinase domain, a C-terminal death domain, and a unique internal region that they called the intermediate domain.

Reference

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Curr. Biol. 19:R17-R19(2009)

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