N-Acylethanolamine Acid Amidase (NAAA)
ASAHL; PLT; N-Acylethanolamine-Hydrolyzing Acid Amidase; N-Acylsphingosine Amidohydrolase Like; Acid ceramidase-like protein
The deduced 359-amino acid protein contains a hydrophobic signal peptide, 4 potential N-myristoylation sites, 5 putative N-glycosylation sites, and several possible phosphorylation sites.
ASAHL and ASAH share 33% amino acid identity. Northern blot analysis revealed a major ASAHL transcript of about 2 kb and minor transcripts of about 2.6, 5.8, and 8.2 kb; the 2.6-kb transcript may have represented cross-hybridization with ASAH. Expression was detected in all tissues tested, with highest expression in liver and kidney, intermediate expression in pancreas, and low expression in lung, heart, brain, and skeletal muscle. Fluorescence-tagged ASAHL, expressed in COS-1 cells, showed a punctate perinuclear distribution that colocalized with lysosomal acid phosphatase.
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Hu01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Hu01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Hu01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Hu01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Hu01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Mu01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Mu01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Mu01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Mu01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Mu01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Ra01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Ra01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Ra01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Ra01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Ra01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Ca01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Ca01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Ca01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Ca01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Ca01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Po01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Po01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Po01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Po01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Po01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Bo01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Bo01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Bo01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Bo01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Bo01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Rb01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Rb01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Rb01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Rb01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Rb01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPS111Mo01 | Recombinant N-Acylethanolamine Acid Amidase (NAAA) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAS111Mo01 | Monoclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IP. |
| PAS111Mo01 | Polyclonal Antibody to N-Acylethanolamine Acid Amidase (NAAA) | WB; IHC; ICC; IF. | |
| Assay Kits | CLS111Mo01 | CLIA Kit for N-Acylethanolamine Acid Amidase (NAAA) | CLIA assay for Antigen Detection |
| ELS111Mo01 | ELISA Kit for N-Acylethanolamine Acid Amidase (NAAA) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Molecular cloning and characterization of a human cDNA and gene encoding a novel acid ceramidase-like protein."
Genomics 62:232-241(1999) [PubMed] [Europe PMC] [Abstract]
"Molecular characterization of N-acylethanolamine-hydrolyzing acid amidase, a novel member of the choloylglycine hydrolase family with structural and functional similarity to acid ceramidase."
J. Biol. Chem. 280:11082-11092(2005) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"A human endogenous long terminal repeat provides a polyadenylation signal to a novel, alternatively spliced transcript in normal placenta."
Gene 121:287-294(1992) [PubMed] [Europe PMC] [Abstract]
"Mass spectrometric characterization of human N-acylethanolamine-hydrolyzing acid amidase."
J. Proteome Res. 11:972-981(2012) [PubMed] [Europe PMC] [Abstract]
"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]