Sphingosine 1 Phosphate Receptor 2 (S1PR2)

EDG5; AGR16; EDG-5; Gpcr13; H218; LPB2; S1P2; Endothelial Differentiation,Sphingolipid G-Protein-Coupled Receptor 5; Sphingosine 1-phosphate receptor Edg-5

SPN	S109
HGNC	3169
MGI	99569
PubMed	22500830
RGD	68334
UniProt	O95136
Wiki	S1PR2

The lysosphingolipid sphingosine 1-phosphate (S1P) regulates cell proliferation, apoptosis, motility, and neurite retraction. Its actions may be both intracellular as a second messenger and extracellular as a receptor ligand. S1P and the structurally related lysolipid mediator lysophosphatidic acid (LPA) signal cells through a set of G protein-coupled receptors known as EDG receptors. Some EDG receptors are S1P receptors; others are LPA receptors.

According to these guidelines, a receptor is to be named with the abbreviation of the natural agonist with the highest potency, followed by a subscripted arabic number. Thus they suggested that the designation EDG5 should be changed to S1P2.

Reference

"Sphingosine 1-phosphate-induced cell proliferation, survival, and related signaling events mediated by G protein-coupled receptors Edg3 and Edg5."
J. Biol. Chem. 275:288-296(2000) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]