Sphingosine 1 Phosphate Receptor 5 (S1PR5)

EDG8; S1P5; S1PR5; SPPR-1; SPPR-2; Endothelial Differentiation,Sphingolipid G-Protein-Coupled Receptor,8; Sphingosine 1-phosphate receptor Edg-8

SPN	S106
HGNC	14299
MGI	2150641
PubMed	23519784
RGD	620566
UniProt	Q9H228
Wiki	S1PR5

According to these guidelines, a receptor is to be named with the abbreviation of the natural agonist with the highest potency, followed by a subscripted arabic number. The conceptualized 400-amino acid rat Edg8 protein shares 42 to 49% amino acid identity with the human S1P receptors EDG1, EDG3, and EDG5. Binding analysis confirmed that expression of Edg8 leads to high-affinity binding for labeled S1P.Widely expressed in the brain, most prominently in the corpus callosum, which is predominantly white matter. Detected in spleen, peripheral blood leukocytes, placenta, lung, aorta, and fetal spleen. Low-level signal detected in many tissue extracts. Isoform 1 is predominently expressed in peripheral tissues, whereas isoform 2 is expressed in brain, spleen and peripheral blood leukocytes.

Reference

"Characterization of a human sphingosine-1-phosphate receptor gene (S1P5) and its differential expression in LGL leukemia."
Biochim. Biophys. Acta 1579:117-123(2002) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors."
Biochemistry 40:14053-14060(2001) [PubMed] [Europe PMC] [Abstract]

"Identification of G protein-coupled receptor genes from the human genome sequence."
FEBS Lett. 520:97-101(2002) [PubMed] [Europe PMC] [Abstract]

Erratum
FEBS Lett. 523:257-257(2002)

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Comparative analysis of human and rat S1P(5) (edg8): differential expression profiles and sensitivities to antagonists."
Biochem. Pharmacol. 64:1243-1250(2002) [PubMed] [Europe PMC] [Abstract]

"Evidence for the presence of the sphingosine-1-phosphate receptor Edg-8 in human radial glial fibers."
Acta Histochem. 106:373-378(2004) [PubMed] [Europe PMC] [Abstract]