Interleukin 31 Receptor A (IL31RA)

CRL; CRL3; GLM-R; GLMR; GPL; IL-31RA; ZcytoR17; •Cytokine receptor-like 3; Gp130-like monocyte receptor

SPN	S050
HGNC	18969
MGI	2180511
PubMed	19690585
RGD	1586478
UniProt	Q8NI17
Wiki	IL31RA

IL31RA is related to gp130, the common receptor subunit for IL6-type cytokines. Expression of IL31RA and OSMR mRNA is induced in activated monocytes, and both mRNAs are constitutively expressed in epithelial cells.The extracellular region of GLMR has a 19-residue signal peptide, followed by a cytokine receptor homology domain, which contains 2 pairs of conserved cysteines and a WSDWS signature motif, and 3 modules with homology to fibronectin type III domains. The intracellular region of GLMR is connected to a single transmembrane domain and contains a box-1 motif, which is probably involved in association with JAK family tyrosine kinases, and 4 tyrosine residues that may serve as docking sites for molecules with SH2 domains.

Reference

"A novel type I cytokine receptor is expressed on monocytes, signals proliferation, and activates STAT-3 and STAT-5."
J. Biol. Chem. 277:16831-16836(2002) [PubMed] [Europe PMC] [Abstract]

"Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice."
Nat. Immunol. 5:752-760(2004) [PubMed] [Europe PMC] [Abstract]

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

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Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

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Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Signal peptide prediction based on analysis of experimentally verified cleavage sites."
Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]

"GPL, a novel cytokine receptor related to GP130 and leukemia inhibitory factor receptor."
J. Biol. Chem. 278:49850-49859(2003) [PubMed] [Europe PMC] [Abstract]

"Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling."
Eur. Cytokine Netw. 15:291-302(2004) [PubMed] [Europe PMC] [Abstract]

"Characterization of the signaling capacities of the novel gp130-like cytokine receptor."
J. Biol. Chem. 279:36112-36120(2004) [PubMed] [Europe PMC] [Abstract]

"IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis."
J. Allergy Clin. Immunol. 117:418-425(2006) [PubMed] [Europe PMC] [Abstract]

"Novel IL31RA gene mutation and ancestral OSMR mutant allele in familial primary cutaneous amyloidosis."
Eur. J. Hum. Genet. 18:26-32(2010) [PubMed] [Europe PMC] [Abstract]