Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)

SCAR2; WAVE2; Verprolin homology domain-containing protein 2

SPN	S040
HGNC	12733
MGI	1098641
PubMed	23435376
RGD	1307299
UniProt	Q9Y6W5
Wiki	WASF2

Wiskott-Aldrich syndrome protein family member 2 is a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members.

The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X.Expressed in all tissues with strongest expression in placenta, lung, and peripheral blood leukocytes, but not in skeletal muscle.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Hu01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Hu01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Hu01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Hu01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Hu01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Mu01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Mu01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Mu01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Mu01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Mu01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Ra01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Ra01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Ra01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Ra01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Ra01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Ca01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Ca01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Ca01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Ca01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Ca01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Po01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Po01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Po01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Po01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Po01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Bo01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Bo01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Bo01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Bo01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Bo01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Rb01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Rb01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Rb01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Rb01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Rb01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPS040Mo01	Recombinant Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAS040Mo01	Monoclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IP.
Antibodies	PAS040Mo01	Polyclonal Antibody to Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	WB; IHC; ICC; IF.
Assay Kits	CLS040Mo01	CLIA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	CLIA assay for Antigen Detection
Assay Kits	ELS040Mo01	ELISA Kit for Wiskott Aldrich Syndrome Protein Family, Member 2 (WASF2)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Identification of two human WAVE/SCAR homologues as general actin regulatory molecules which associate with the Arp2/3 complex."
Biochem. Biophys. Res. Commun. 260:296-302(1999) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biological annotation of human chromosome 1."
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"IRSp53 is an essential intermediate between Rac and WAVE in the regulation of membrane ruffling."
Nature 408:732-735(2000) [PubMed] [Europe PMC] [Abstract]

"Purification and architecture of the ubiquitous Wave complex."
Proc. Natl. Acad. Sci. U.S.A. 101:4379-4383(2004) [PubMed] [Europe PMC] [Abstract]

"Structure and control of the actin regulatory WAVE complex."
Nature 468:533-538(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"HCMV pUL135 remodels the actin cytoskeleton to impair immune recognition of infected cells."
Cell Host Microbe 16:201-214(2014) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Actin-bound structures of Wiskott-Aldrich syndrome protein (WASP)-homology domain 2 and the implications for filament assembly."
Proc. Natl. Acad. Sci. U.S.A. 102:16644-16649(2005) [PubMed] [Europe PMC] [Abstract]