Glutamate Receptor, Ionotropic, AMPA 1 (GRIA1)

GLUH1; GLUR1; GLURA; HBGR1; GluR-K1; AMPA-selective glutamate receptor 1

SPN	S012
HGNC	4571
MGI	95808
PubMed	18484081
RGD	621531
UniProt	P42261
Wiki	GRIA1

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. The classification of glutamate receptors is based on their activation by different pharmacologic agonists. The GRIA1 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Each of the members (GRIA1-4) include flip and flop isoforms generated by alternative RNA splicing. The receptor subunits encoded by each isoform vary in their signal transduction properties. The isoform presented here is the flop isoform. In situ hybridization experiments showed that human GRIA1 mRNA is present in granule and pyramidal cells in the hippocampal formation.

Reference

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