Glutamate Receptor, Ionotropic, AMPA 2 (GRIA2)

GLUR2; GLURB; HBGR2; GluR-K2; AMPA-selective glutamate receptor 2

SPN	S011
HGNC	4572
MGI	95809
PubMed	22644307
RGD	61862
UniProt	P42262
Wiki	GRIA2

GRIA2 belongs to a family of glutamate receptors that are sensitive to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA), and function as ligand-activated cation channels. These channels are assembled from 4 related subunits, GRIA1-4. The subunit encoded by this gene (GRIA2) is subject to RNA editing within the second transmembrane domain, which is thought to render the channel impermeable to Ca(2+). Human and animal studies suggest that pre-mRNA editing is essential for brain function, and defective GRIA2 RNA editing at the Q/R site may be relevant to amyotrophic lateral sclerosis (ALS) etiology. Alternative splicing, resulting in transcript variants encoding different isoforms, has been noted for this gene, which includes the generation of flip and flop isoforms that vary in their signal transduction properties.

Reference

"Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain."
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Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue."
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"Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors."
Neuron 40:1199-1212(2003) [PubMed] [Europe PMC] [Abstract]

"The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands."
J. Biol. Chem. 279:41393-41397(2004) [PubMed] [Europe PMC] [Abstract]

"A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors."
J. Neurosci. 33:9840-9845(2013) [PubMed] [Europe PMC] [Abstract]

"Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors."
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J. Med. Chem. 53:5801-5812(2010) [PubMed] [Europe PMC] [Abstract]

"Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity."
Bioorg. Med. Chem. Lett. 21:3358-3361(2011) [PubMed] [Europe PMC] [Abstract]