Glutamate Receptor, Ionotropic, AMPA 3 (GRIA3)

GLUR-K3; GLUR3; GLURC; gluR-C; AMPA-selective glutamate receptor 3

SPN	S010
HGNC	4573
MGI	95810
PubMed	17568425
RGD	70958
UniProt	P42263
Wiki	GRIA3

Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits, each possessing transmembrane regions, and all arranged to form a ligand-gated ion channel. The classification of glutamate receptors is based on their activation by different pharmacologic agonists.

Glutamate receptor 3 belongs to a family of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors. Alternative splicing at this locus results in several different isoforms which may vary in their signal transduction properties.

Reference

"Human glutamate receptor hGluR3 flip and flop isoforms: cloning and sequencing of the cDNAs and primary structure of the proteins."
Biochim. Biophys. Acta 1219:563-566(1994) [PubMed] [Europe PMC] [Abstract]

"Characterization of the human glutamate receptor subunit 3 gene (GRIA3), a candidate for bipolar disorder and nonspecific X-linked mental retardation."
Genomics 62:356-368(1999) [PubMed] [Europe PMC] [Abstract]

"Candidate gene analysis in Rett syndrome and the identification of 21 SNPs in Xq."
Am. J. Med. Genet. 90:69-71(2000) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
Neuron 68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]

"Mutations in ionotropic AMPA receptor 3 alter channel properties and are associated with moderate cognitive impairment in humans."
Proc. Natl. Acad. Sci. U.S.A. 104:18163-18168(2007) [PubMed] [Europe PMC] [Abstract]