Glutamate Receptor, Ionotropic, N-Methyl-D-Aspartate 2B (GRIN2B)

NMDAR2B; NR2B; hNR3; Glutamate [NMDA] receptor subunit epsilon-2; N-methyl D-aspartate receptor subtype 2B; N-methyl-D-aspartate receptor subunit 3

SPN	S006
HGNC	4586
MGI	95821
PubMed	21499247
RGD	2738
UniProt	Q13224
Wiki	GRIN2B

The N-methyl-D-aspartate (NMDA) receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. Functional NMDA receptors appear to be composed (minimally) of an invariant subunit (NMDAR1) and 1 of several variable subunits . Each of the variable subunits exhibits a distinct distribution in the adult brain. For example, postnatally, NMDA receptors containing the NMDAR2B subunit are primarily localized to the hippocampus and forebrain. The sequence of the predicted 1,484-amino acid human protein is 98% and 96% identical to the sequences of the rat and mouse Nmdar2b proteins, respectively.

Reference

"Human N-methyl-D-aspartate receptor modulatory subunit hNR3: cloning and sequencing of the cDNA and primary structure of the protein."
Biochim. Biophys. Acta 1260:105-108(1995) [PubMed] [Europe PMC] [Abstract]

"Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors."
J. Pharmacol. Exp. Ther. 278:808-816(1996) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Mapping of the human NMDAR2B receptor subunit gene (GRIN2B) to chromosome 12p12."
Genomics 22:216-218(1994) [PubMed] [Europe PMC] [Abstract]

"mRNA distribution in adult human brain of GRIN2B, a N-methyl-D-aspartate (NMDA) receptor subunit."
Neurosci. Lett. 239:49-53(1997) [PubMed] [Europe PMC] [Abstract]

"Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase."
J. Biol. Chem. 275:21477-21485(2000) [PubMed] [Europe PMC] [Abstract]

"Mutations in GRIN2A and GRIN2B encoding regulatory subunits of NMDA receptors cause variable neurodevelopmental phenotypes."
Nat. Genet. 42:1021-1026(2010) [PubMed] [Europe PMC] [Abstract]

"Diagnostic exome sequencing in persons with severe intellectual disability."
N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]

"GRIN2B mutations in West syndrome and intellectual disability with focal epilepsy."
Ann. Neurol. 75:147-154(2014) [PubMed] [Europe PMC] [Abstract]