Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)

ALDH3; ALDHIII; Aldehyde Dehydrogenase,Dimeric NADP-Preferring; Aldehyde dehydrogenase 3

SPN	R982
HGNC	405
MGI	1353451
PubMed	22206977
RGD	2088
UniProt	P30838
Wiki	ALDH3A1

Aldehyde dehydrogenases oxidize various aldehydes to the corresponding acids. They are involved in the detoxification of alcohol-derived acetaldehyde and in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. The enzyme encoded by this gene forms a cytoplasmic homodimer that preferentially oxidizes aromatic and medium-chain (6 carbons or more) saturated and unsaturated aldehyde substrates. It is thought to promote resistance to UV and 4-hydroxy-2-nonenal-induced oxidative damage in the cornea. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes. ALDH3A1 is located within the Smith-Magenis syndrome region on chromosome 17. Multiple alternatively spliced variants, encoding the same protein, have been identified.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Hu01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Hu01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Hu01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Hu01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Hu01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Mu01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Mu01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Mu01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Mu01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Mu01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Ra01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Ra01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Ra01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Ra01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Ra01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Ca01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Ca01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Ca01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Ca01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Ca01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Po01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Po01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Po01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Po01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Po01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Bo01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Bo01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Bo01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Bo01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Bo01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Rb01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Rb01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Rb01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Rb01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Rb01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	RPR982Mo01	Recombinant Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies	MAR982Mo01	Monoclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IP.
Antibodies	PAR982Mo01	Polyclonal Antibody to Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	WB; IHC; ICC; IF.
Assay Kits	CLR982Mo01	CLIA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	CLIA assay for Antigen Detection
Assay Kits	ELR982Mo01	ELISA Kit for Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1)	Enzyme-linked immunosorbent assay for Antigen Detection

Reference

"Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli."
J. Biol. Chem. 267:3030-3037(1992) [PubMed] [Europe PMC] [Abstract]

"Human stomach aldehyde dehydrogenase, ALDH3."
Adv. Exp. Med. Biol. 328:141-152(1993) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. 'Variable' and 'constant' enzymes within the alcohol and aldehyde dehydrogenase families."
FEBS Lett. 283:85-88(1991) [PubMed] [Europe PMC] [Abstract]

"Biochemical, immunological, and molecular characterization of a 'high Km' aldehyde dehydrogenase."
Adv. Exp. Med. Biol. 284:43-52(1991) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases."
J. Biol. Chem. 286:43486-43494(2011) [PubMed] [Europe PMC] [Abstract]

"Mutations associated with Sjogren-Larsson syndrome."
Ann. Hum. Genet. 61:235-242(1997) [PubMed] [Europe PMC] [Abstract]