Interleukin 1 Zeta (IL1z)

IL1F7; IL37; FIL1; FIL1(ZETA); FIL1Z; IL-1F7; IL-1H4; IL-1RP1; IL1H4; IL1RP1; Interleukin 37; Interleukin-1-Related Protein; Interleukin 1 Family, Member 7

SPN	R970
HGNC	15563
UniProt	Q9NZH6

IL1zis a member of the interleukin 1 cytokine family. This cytokine can bind to, and may be a ligand for interleukin 18 receptor (IL18R1/IL-1Rrp). This cytokine also binds to interleukin 18 binding protein (IL18BP), an inhibitory binding protein of interleukin 18 (IL18), and subsequently forms a complex with IL18 receptor beta subunit, and through which it inhibits the activity of IL18. This gene along with eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Five alternatively spliced transcript variants encoding distinct isoforms have been reported.

Isoform A, isoform B and isoform C are expressed in testis, colon, placenta, lung and lymph node. Isoform D and isoform E were found only in testis and bone marrow. Whereas only isoform A is found in brain, only isoform B in kidney and only isoform C in heart.

Organism species: Homo sapiens (Human)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	R970Hu01	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	MR970Hu22	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	PR970Hu01	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	LR970Hu71	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	KER970Hu	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	KCR970Hu	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE	CATALOG NO.	PRODUCT NAME	APPLICATIONS
Proteins	NONE	Recombinant Interleukin 1 Zeta (IL1z)	Positive Control; Immunogen; SDS-PAGE; WB.
Proteins	NONE	Native Interleukin 1 Zeta (IL1z)	Bioactivity
Antibodies	NONE	Monoclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IP.
	NONE	Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	WB; IHC; ICC; IF.
	NONE	Biotin Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	ELISA(Det);IC; IH; IH(P); WB
	NONE	APC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	IHC, WB
	NONE	HRP Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Simple Western; WB
	NONE	PE Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry
	NONE	FITC Linked-Polyclonal Antibody to Interleukin 1 Zeta (IL1z)	Flow Cytometry;ICC/IF
Assay Kits	NONE	ELISA Kit for Interleukin 1 Zeta (IL1z)	Enzyme-linked immunosorbent assay for Antigen Detection
Assay Kits	NONE	CLIA kit for Interleukin 1 Zeta (IL1z)	CLIA assay for Antigen Detection

Reference

"Identification and initial characterization of four novel members of the interleukin-1 family."
J. Biol. Chem. 275:10308-10314(2000) [PubMed] [Europe PMC] [Abstract]

"IL-1H, an interleukin 1-related protein that binds IL-18 receptor/IL-1Rrp."
Cytokine 13:1-7(2001) [PubMed] [Europe PMC] [Abstract]

"Four new members expand the IL-1 superfamily."
J. Biol. Chem. 275:1169-1175(2000) [PubMed] [Europe PMC] [Abstract]

"Genomic organization of the interleukin-1 locus."
Genomics 79:726-733(2002) [PubMed] [Europe PMC] [Abstract]

"Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
Nat. Methods 5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The IL-1 family member 7b translocates to the nucleus and down-regulates proinflammatory cytokines."
J. Immunol. 180:5477-5482(2008) [PubMed] [Europe PMC] [Abstract]

"IL-37 is a fundamental inhibitor of innate immunity."
Nat. Immunol. 11:1014-1022(2010) [PubMed] [Europe PMC] [Abstract]