Diacylglycerol Kinase Gamma (DGKg)

DAGK3; DGK-GAMMA; Diglyceride kinase gamma

SPN	R963
HGNC	2853
MGI	105060
PubMed	20215397
RGD	2499
UniProt	P49619
Wiki	DGKG

Diacylglycerol kinase gamma is a member of the type I subfamily of diacylglycerol kinases, which are involved in lipid metabolism. These enzymes generate phosphatidic acid by catalyzing the phosphorylation of diacylglycerol, a fundamental lipid second messenger that activates numerous proteins, including protein kinase C isoforms, Ras guanyl nucleotide-releasing proteins and some transient receptor potential channels. Diacylglycerol kinase gamma has been implicated in cell cycle regulation and in the negative regulation of macrophage differentiation in leukemia cells. Multiple transcript variants encoding different isoforms have been found for this gene.Predominantly expressed in retina and in a much lesser extent in the brain. Other tissues contain extremely low levels of DGK-gamma.

Reference

"Molecular cloning of a diacylglycerol kinase isozyme predominantly expressed in human retina with a truncated and inactive enzyme expression in most other human cells."
J. Biol. Chem. 269:18492-18498(1994) [PubMed] [Europe PMC] [Abstract]

"Mapping and genomic characterization of the gene encoding diacylglycerol kinase gamma (DAGK3): assessment of its role in dominant optic atrophy (OPA1)."
Hum. Genet. 104:99-105(1999) [PubMed] [Europe PMC] [Abstract]

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