Glycine Receptor Alpha 2 (GLRa2)

GLR

SPN	R955
HGNC	4327
MGI	95748
PubMed	19924257
RGD	2705
UniProt	P23416
Wiki	GLRA2

The GLRA2 gene encodes the alpha-2 subunit of the glycine receptor. The alpha-1 subunit is encoded by the GLRA1 gene, which maps to chromosome 5q32. The GLRA2 gene is expressed in fetal brain and spinal cord, and the GLRA1 gene is expressed predominantly in adult brain and spinal cord .

Grenningloh et al. (1987) cloned and sequenced cDNAs of the strychnine-binding subunit of the rat glycine receptor, a neurotransmitter-gated chloride channel protein of the central nervous system. They found that the deduced polypeptide shows significant structural and amino acid sequence homology with nicotinic acetylcholine receptor proteins, indicating that they belong to a family of genes encoding neurotransmitter-gated ion channels.

Reference

"Alpha subunit variants of the human glycine receptor: primary structures, functional expression and chromosomal localization of the corresponding genes."
EMBO J. 9:771-776(1990) [PubMed] [Europe PMC] [Abstract]

"Analysis of the genomic structure of the human glycine receptor alpha-2 subunit gene and exclusion of this gene as a candidate for Rett syndrome."
Am. J. Med. Genet. 78:176-178(1998) [PubMed] [Europe PMC] [Abstract]

"Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants."
Br. J. Pharmacol. 143:19-26(2004) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence of the human X chromosome."
Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the human alpha 2 subunit gene of the glycine receptor: use of vectorette and Alu-exon PCR."
Genome Res. 6:1200-1206(1996) [PubMed] [Europe PMC] [Abstract]