Large Multifunctional Peptidase 2 (LMP2)

PSMB9; Proteasome(Prosome,Macropain)Subunit Beta Type 9; Macropain chain 7; Multicatalytic endopeptidase complex chain 7; Really interesting new gene 12 protein

SPN	R939
HGNC	9546
MGI	1346526
PubMed	17462577
RGD	3427
UniProt	P28065
Wiki	PSMB9

Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides.

LMP2 isa member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. LMP2 is located in the class II region of the MHC (major histocompatibility complex). Expression of this gene is induced by gamma interferon and this gene product replaces catalytic subunit 1 (proteasome beta 6 subunit) in the immunoproteasome. Proteolytic processing is required to generate a mature subunit.

Reference

"The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing."
Eur. J. Immunol. 23:860-866(1993) [PubMed] [Europe PMC] [Abstract]

"DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing."
J. Mol. Biol. 228:433-441(1992) [PubMed] [Europe PMC] [Abstract]

"Second proteasome-related gene in the human MHC class II region."
Nature 353:667-668(1991) [PubMed] [Europe PMC] [Abstract]

"Alternative exon usage and processing of the major histocompatibility complex-encoded proteasome subunits."
J. Biol. Chem. 267:22131-22140(1992) [PubMed] [Europe PMC] [Abstract]

"Evolutionary dynamics of non-coding sequences within the class II region of the human MHC."
J. Mol. Biol. 255:1-13(1996) [PubMed] [Europe PMC] [Abstract]

"Major histocompatibility-encoded human proteasome LMP2. Genomic organization and a new form of mRNA."
J. Biol. Chem. 270:1966-1970(1995) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and analysis of human chromosome 6."
Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Replacement of proteasome subunits X and Y by LMP7 and LMP2 induced by interferon-gamma for acquirement of the functional diversity responsible for antigen processing."
FEBS Lett. 343:85-88(1994) [PubMed] [Europe PMC] [Abstract]

"Analysis of mammalian 20S proteasome biogenesis: the maturation of beta-subunits is an ordered two-step mechanism involving autocatalysis."
EMBO J. 15:6887-6898(1996) [PubMed] [Europe PMC] [Abstract]

"Proteasome subunits X and Y alter peptidase activities in opposite ways to the interferon-gamma-induced subunits LMP2 and LMP7."
J. Biol. Chem. 271:17275-17280(1996) [PubMed] [Europe PMC] [Abstract]

"Tumor necrosis factor-alpha induces coordinated changes in major histocompatibility class I presentation pathway, resulting in increased stability of class I complexes at the cell surface."
Blood 98:1108-1115(2001) [PubMed] [Europe PMC] [Abstract]

"Bipartite regulation of different components of the MHC class I antigen-processing machinery during dendritic cell maturation."
Int. Immunol. 13:1515-1523(2001) [PubMed] [Europe PMC] [Abstract]

"Human immunodeficiency virus-1 Tat protein interacts with distinct proteasomal alpha and beta subunits."
FEBS Lett. 553:200-204(2003) [PubMed] [Europe PMC] [Abstract]

"Potential effects of tetrodotoxin exposure to human glial cells postulated using microarray approach."
Toxicon 44:597-608(2004) [PubMed] [Europe PMC] [Abstract]

"IRF-1 mediates upregulation of LMP7 by IFN-gamma and concerted expression of immunosubunits of the proteasome."
FEBS Lett. 579:2781-2787(2005) [PubMed] [Europe PMC] [Abstract]

"The catalytic subunit of the proteasome is engaged in the entire process of estrogen receptor-regulated transcription."
EMBO J. 25:4223-4233(2006) [PubMed] [Europe PMC] [Abstract]

"Heat shock up-regulates lmp2 and lmp7 and enhances presentation of immunoproteasome-dependent epitopes."
J. Immunol. 177:8393-8399(2006) [PubMed] [Europe PMC] [Abstract]

"Genome-wide gene expression differences in Crohn's disease and ulcerative colitis from endoscopic pinch biopsies: insights into distinctive pathogenesis."
Inflamm. Bowel Dis. 13:807-821(2007) [PubMed] [Europe PMC] [Abstract]

"CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1."
Mol. Cell. Biol. 28:6208-6222(2008) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"Complex association analysis of Graves disease using a set of polymorphic markers."
Mol. Genet. Metab. 70:214-218(2000) [PubMed] [Europe PMC] [Abstract]