Histone Deacetylase 4 (HDAC4)

HD4; HDAC-A; HDACA

SPN	R895
HGNC	14063
MGI	3036234
PubMed	23434587
RGD	619979
UniProt	P56524
Wiki	HDAC4

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA.

HDAC4belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3.^[3] Furthermore, HDAC4 is required for TGFbeta1-induced myofibroblastic differentiation.

Reference

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"HDAC4 deacetylase associates with and represses the MEF2 transcription factor."
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