Histone Deacetylase 6 (HDAC6)

HD6; JM21

SPN	R893
HGNC	14064
MGI	1333752
PubMed	22457490
RGD	619981
UniProt	Q9UBN7
Wiki	HDAC6

HDAC6 belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.Sequence analysis predicted that the 1,216-amino acid HDAC6 protein consists of an apparent internal dimer containing 2 highly homologous catalytic domains, the first beginning at residue 215 and the second at residue 610. Northern blot analysis detected expression of a 5.0-kb HDAC6 transcript that was highest in heart, liver, kidney, and pancreas. Functional analysis confirmed that HDAC6 possesses deacetylation activity against all 4 core histones and that the 2 catalytic domains function independently.

Reference

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"HDAC6 is a microtubule-associated deacetylase."
Nature 417:455-458(2002) [PubMed] [Europe PMC] [Abstract]

"The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase."
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"HEF1-dependent Aurora A activation induces disassembly of the primary cilium."
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"The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition."
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"Differential regulation of estrogen receptor alpha expression in breast cancer cells by metastasis-associated protein 1."
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"Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation."
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"Crystal structure of human HDAC6 zinc finger domain."
Submitted (FEB-2008) to the PDB data bank

"Crystal structure of human HDAC6 zinc finger domain and ubiquitin C-terminal peptide RLRGG."
Submitted (APR-2009) to the PDB data bank