Sirtuin 3 (SIRT3)
SIR2L3; Silent Mating Type Information Regulation 2 Homolog 3; NAD-dependent protein deacetylase sirtuin-3, mitochondrial; SIR2-like protein 3; Regulatory protein SIR2 homolog 3
Organism species: Homo sapiens (Human)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Hu01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Hu01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Hu01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Hu01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Hu01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Mu01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Mu01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Mu01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Mu01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Mu01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Ra01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Ra01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Ra01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Ra01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Ra01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Ca01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Ca01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Ca01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Ca01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Ca01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Po01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Po01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Po01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Po01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Po01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Bo01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Bo01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Bo01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Bo01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Bo01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Rb01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Rb01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Rb01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Rb01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Rb01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
| PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
|---|---|---|---|
| Proteins | RPR886Mo01 | Recombinant Sirtuin 3 (SIRT3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | MAR886Mo01 | Monoclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IP. |
| PAR886Mo01 | Polyclonal Antibody to Sirtuin 3 (SIRT3) | WB; IHC; ICC; IF. | |
| Assay Kits | CLR886Mo01 | CLIA Kit for Sirtuin 3 (SIRT3) | CLIA assay for Antigen Detection |
| ELR886Mo01 | ELISA Kit for Sirtuin 3 (SIRT3) | Enzyme-linked immunosorbent assay for Antigen Detection |
Reference
"Characterization of five human cDNAs with homology to the yeast SIR2 gene: Sir2-like proteins (sirtuins) metabolize NAD and may have protein ADP-ribosyltransferase activity."
Biochem. Biophys. Res. Commun. 260:273-279(1999) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase."
J. Cell Biol. 158:647-657(2002) [PubMed] [Europe PMC] [Abstract]
"SIRT3, a human SIR2 homologue, is an NAD-dependent deacetylase localized to mitochondria."
Proc. Natl. Acad. Sci. U.S.A. 99:13653-13658(2002) [PubMed] [Europe PMC] [Abstract]
"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."
Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
"Reversible lysine acetylation controls the activity of the mitochondrial enzyme acetyl-CoA synthetase 2."
Proc. Natl. Acad. Sci. U.S.A. 103:10224-10229(2006) [PubMed] [Europe PMC] [Abstract]
"The human SIRT3 protein deacetylase is exclusively mitochondrial."
Biochem. J. 411:279-285(2008) [PubMed] [Europe PMC] [Abstract]
"Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5."
J. Mol. Biol. 382:790-801(2008) [PubMed] [Europe PMC] [Abstract]
"A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis."
Proc. Natl. Acad. Sci. U.S.A. 105:14447-14452(2008) [PubMed] [Europe PMC] [Abstract]
"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
"SIRT3 deacetylates ATP synthase F1 complex proteins in response to nutrient and exercise-induced stress."
Antioxid. Redox Signal. 21:551-564(2014) [PubMed] [Europe PMC] [Abstract]
"SIRT3 regulates long-chain acyl-coA dehydrogenase by deacetylating conserved lysines near the active site."
J. Biol. Chem. 288:33837-33847(2013) [PubMed] [Europe PMC] [Abstract]
"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
"Crystal structures of human SIRT3 displaying substrate-induced conformational changes."
J. Biol. Chem. 284:24394-24405(2009) [PubMed] [Europe PMC] [Abstract]
"Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanism."
Acta Crystallogr. D 69:1423-1432(2013) [PubMed] [Europe PMC] [Abstract]