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Sirtuin 6 (SIRT6)

SIR2L6; Silent Mating Type Information Regulation 2 Homolog 6; Mono-ADP-Ribosyltransferase Sirtuin-6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6

SIRT6 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.Sirtuins can be divided into 4 main classes in eukaryotes based on amino acid sequence motifs, with yeast Sir2 belonging to class Ia. The deduced 355-amino acid SIRT6 protein is a class IV sirtuin, a class not present in prokaryotes.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins R883Hu01 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies MR883Hu21 Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
PR883Hu01 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
LR883Hu71 Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits KER883Hu ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins R883Mu01 Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
PR883Mu01 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
LR883Mu71 Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits KER883Mu ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
PR883Ra01 Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 6 (SIRT6) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 6 (SIRT6) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 6 (SIRT6) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 6 (SIRT6) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 6 (SIRT6) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 6 (SIRT6) CLIA assay for Antigen Detection

Reference

"Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins."
Biochem. Biophys. Res. Commun. 273:793-798(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence and biology of human chromosome 19."
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."
Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]

"SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin."
Nature 452:492-496(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

"SIRT6 links histone H3 lysine 9 deacetylation to NF-kappaB-dependent gene expression and organismal life span."
Cell 136:62-74(2009) [PubMed] [Europe PMC] [Abstract]

"Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6."
Cell Cycle 8:2664-2666(2009) [PubMed] [Europe PMC] [Abstract]

"Human SIRT6 promotes DNA end resection through CtIP deacetylation."
Science 329:1348-1353(2010) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Structure and biochemical functions of SIRT6."
J. Biol. Chem. 286:14575-14587(2011) [PubMed] [Europe PMC] [Abstract]