Sirtuin 7 (SIRT7)
SIR2L7; NAD-Dependent Deacetylase Sirtuin-7; Silent Mating Type Information Regulation 2 Homolog 7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7
NAD-dependent deacetylase sirtuin-7 is a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Sir2 is short for Silent mating type Information Regulation-2 and sirtuin stands for Sir2-homolog. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.
Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.
Organism species: Homo sapiens (Human)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | R882Hu01 | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | MR882Hu21 | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
PR882Hu01 | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | KER882Hu | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Mus musculus (Mouse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Rattus norvegicus (Rat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
PR882Ra01 | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | KER882Ra | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Canis familiaris; Canine (Dog)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Sus scrofa; Porcine (Pig)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Bos taurus; Bovine (Cattle)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Rhesus monkey (Simian)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Chicken (Gallus)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Ovis aries; Ovine (Sheep)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Oryctolagus cuniculus (Rabbit)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Cavia (Guinea pig )
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Equus caballus; Equine (Horse)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Capra hircus; Caprine (Goat)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Organism species: Pan-species (General)
PRODUCT TYPE | CATALOG NO. | PRODUCT NAME | APPLICATIONS |
---|---|---|---|
Proteins | NONE | Recombinant Sirtuin 7 (SIRT7) | Positive Control; Immunogen; SDS-PAGE; WB. |
NONE | Native Sirtuin 7 (SIRT7) | Bioactivity | |
Antibodies | NONE | Monoclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IP. |
NONE | Polyclonal Antibody to Sirtuin 7 (SIRT7) | WB; IHC; ICC; IF. | |
NONE | Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | ELISA(Det);IC; IH; IH(P); WB | |
NONE | APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | IHC, WB | |
NONE | HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Simple Western; WB | |
NONE | PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry | |
NONE | FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) | Flow Cytometry;ICC/IF | |
Assay Kits | NONE | ELISA Kit for Sirtuin 7 (SIRT7) | Enzyme-linked immunosorbent assay for Antigen Detection |
NONE | CLIA kit for Sirtuin 7 (SIRT7) | CLIA assay for Antigen Detection |
Reference
"Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins."
Biochem. Biophys. Res. Commun. 273:793-798(2000) [PubMed] [Europe PMC] [Abstract]
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
"Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues."
Br. J. Cancer 86:917-923(2002) [PubMed] [Europe PMC] [Abstract]
Erratum
Br. J. Cancer 87:1479-1479(2002) [PubMed] [Europe PMC] [Abstract]
"'SIRT8' expressed in thyroid cancer is actually SIRT7."
Br. J. Cancer 87:1479-1479(2002) [PubMed] [Europe PMC] [Abstract]
"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."
Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]
"Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription."
Genes Dev. 20:1075-1080(2006) [PubMed] [Europe PMC] [Abstract]
"Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis."
J. Cell Sci. 122:489-498(2009) [PubMed] [Europe PMC] [Abstract]
"Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription."
Mol. Cell. Proteomics 11:M111.015156.01-M111.015156.17(2012) [PubMed] [Europe PMC] [Abstract]
"SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation."
Nature 487:114-118(2012) [PubMed] [Europe PMC] [Abstract]