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Sirtuin 7 (SIRT7)

SIR2L7; NAD-Dependent Deacetylase Sirtuin-7; Silent Mating Type Information Regulation 2 Homolog 7; Regulatory protein SIR2 homolog 7; SIR2-like protein 7

NAD-dependent deacetylase sirtuin-7 is  a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Sir2 is short for Silent mating type Information Regulation-2 and sirtuin stands for Sir2-homolog. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA.

Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family.

Organism species: Homo sapiens (Human)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins R882Hu01 Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies MR882Hu21 Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
PR882Hu01 Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits KER882Hu ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Mus musculus (Mouse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Rattus norvegicus (Rat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
PR882Ra01 Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits KER882Ra ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Canis familiaris; Canine (Dog)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Sus scrofa; Porcine (Pig)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Bos taurus; Bovine (Cattle)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Rhesus monkey (Simian)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Chicken (Gallus)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Ovis aries; Ovine (Sheep)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Oryctolagus cuniculus (Rabbit)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Cavia (Guinea pig )

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Equus caballus; Equine (Horse)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Capra hircus; Caprine (Goat)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Organism species: Pan-species (General)

PRODUCT TYPE CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins NONE Recombinant Sirtuin 7 (SIRT7) Positive Control; Immunogen; SDS-PAGE; WB.
NONE Native Sirtuin 7 (SIRT7) Bioactivity
Antibodies NONE Monoclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IP.
NONE Polyclonal Antibody to Sirtuin 7 (SIRT7) WB; IHC; ICC; IF.
NONE Biotin Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) ELISA(Det);IC; IH; IH(P); WB
NONE APC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) IHC, WB
NONE HRP Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Simple Western; WB
NONE PE Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry
NONE FITC Linked-Polyclonal Antibody to Sirtuin 7 (SIRT7) Flow Cytometry;ICC/IF
Assay Kits NONE ELISA Kit for Sirtuin 7 (SIRT7) Enzyme-linked immunosorbent assay for Antigen Detection
NONE CLIA kit for Sirtuin 7 (SIRT7) CLIA assay for Antigen Detection

Reference

"Phylogenetic classification of prokaryotic and eukaryotic Sir-2 like proteins."
Biochem. Biophys. Res. Commun. 273:793-798(2000) [PubMed] [Europe PMC] [Abstract]

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"Isolation of a SIR-like gene, SIR-T8, that is overexpressed in thyroid carcinoma cell lines and tissues."
Br. J. Cancer 86:917-923(2002) [PubMed] [Europe PMC] [Abstract]

Erratum
Br. J. Cancer 87:1479-1479(2002) [PubMed] [Europe PMC] [Abstract]

"'SIRT8' expressed in thyroid cancer is actually SIRT7."
Br. J. Cancer 87:1479-1479(2002) [PubMed] [Europe PMC] [Abstract]

"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins."
Mol. Biol. Cell 16:4623-4635(2005) [PubMed] [Europe PMC] [Abstract]

"Mammalian Sir2 homolog SIRT7 is an activator of RNA polymerase I transcription."
Genes Dev. 20:1075-1080(2006) [PubMed] [Europe PMC] [Abstract]

"Involvement of SIRT7 in resumption of rDNA transcription at the exit from mitosis."
J. Cell Sci. 122:489-498(2009) [PubMed] [Europe PMC] [Abstract]

"Functional proteomics establishes the interaction of SIRT7 with chromatin remodeling complexes and expands its role in regulation of RNA polymerase I transcription."
Mol. Cell. Proteomics 11:M111.015156.01-M111.015156.17(2012) [PubMed] [Europe PMC] [Abstract]

"SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation."
Nature 487:114-118(2012) [PubMed] [Europe PMC] [Abstract]