Filamin B Beta (FLNb)

ABP-278; AOI; FH1; FLN1L; LRS1; SCT; TABP; TAP; Actin Binding Protein 278; Actin-binding-like protein; Thyroid autoantigen; Filamin-3; Truncated actin-binding protein

SPN	R868
HGNC	3755
MGI	2446089
PubMed	15994868
RGD	1311915
UniProt	O75369
Wiki	FLNB

Filamin B, beta isa human cytoplasmic protein. It regulates intracellular communication and signalling by cross-linking the protein actin to allow direct communication between the cell membrane and cytoskeletal network, to control and guide proper skeletal development.

Mutations in the FLNB gene are involved in several lethal bone dysplasias, including boomerang dysplasia and atelosteogenesis type I.Like ABP280, the predicted 2,602-amino acid protein contains an N-terminal actin-binding domain, a backbone of 24 tandem repeats, and 2 hinge regions. Excluding the unique first hinge region of beta-filamin, the sequences of beta-filamin and ABP280 are 70% identical.

Reference

"Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha."
J. Biol. Chem. 273:17531-17538(1998) [PubMed] [Europe PMC] [Abstract]

"A novel human actin-binding protein homologue that binds to platelet glycoprotein Ibalpha."
Blood 92:1268-1276(1998) [PubMed] [Europe PMC] [Abstract]

"Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin (beta) subunits."
J. Cell Biol. 156:361-376(2002) [PubMed] [Europe PMC] [Abstract]

"Genomic structure and fine mapping of the two human filamin gene paralogues FLNB and FLNC and comparative analysis of the filamin gene family."
Hum. Genet. 107:597-611(2000) [PubMed] [Europe PMC] [Abstract]

"Fine expression profiling of full-length transcripts using a size-unbiased cDNA library prepared with the vector-capping method."
DNA Res. 15:123-136(2008) [PubMed] [Europe PMC] [Abstract]

"Vector-capping: a simple method for preparing a high-quality full-length cDNA library."
DNA Res. 12:53-62(2005) [PubMed] [Europe PMC] [Abstract]

"The full-ORF clone resource of the German cDNA consortium."
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

"The DNA sequence, annotation and analysis of human chromosome 3."
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]

"The SH2-containing inositol polyphosphate 5-phosphatase, SHIP-2, binds filamin and regulates submembraneous actin."
J. Cell Biol. 155:1065-1079(2001) [PubMed] [Europe PMC] [Abstract]

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

"Interaction of presenilins with the filamin family of actin-binding proteins."
J. Neurosci. 18:914-922(1998) [PubMed] [Europe PMC] [Abstract]

"Cloning from the thyroid of a protein related to actin binding protein that is recognized by Graves disease immunoglobulins."
Proc. Natl. Acad. Sci. U.S.A. 90:5994-5998(1993) [PubMed] [Europe PMC] [Abstract]

"Hepatitis B virus core protein interacts with the C-terminal region of actin-binding protein."
J. Biomed. Sci. 7:160-168(2000) [PubMed] [Europe PMC] [Abstract]

"Filamin A and filamin B are co-expressed within neurons during periods of neuronal migration and can physically interact."
Hum. Mol. Genet. 11:2845-2854(2002) [PubMed] [Europe PMC] [Abstract]

"A new member of the LIM protein family binds to filamin B and localizes at stress fibers."
J. Biol. Chem. 278:12175-12181(2003) [PubMed] [Europe PMC] [Abstract]

"The limits of promiscuity: isoform-specific dimerization of filamins."
Biochemistry 42:430-439(2003) [PubMed] [Europe PMC] [Abstract]

"The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins."
J. Cell Sci. 118:3739-3749(2005) [PubMed] [Europe PMC] [Abstract]

"Structural and functional aspects of filamins."
Biochim. Biophys. Acta 1538:99-117(2001) [PubMed] [Europe PMC] [Abstract]

"Filamins as integrators of cell mechanics and signalling."
Nat. Rev. Mol. Cell Biol. 2:138-145(2001) [PubMed] [Europe PMC] [Abstract]

"A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

"A quantitative atlas of mitotic phosphorylation."
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

"The E3 ubiquitin ligase specificity subunit ASB2beta is a novel regulator of muscle differentiation that targets filamin B to proteasomal degradation."
Cell Death Differ. 16:921-932(2009) [PubMed] [Europe PMC] [Abstract]

"ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway."
EMBO Rep. 10:374-380(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

"Initial characterization of the human central proteome."
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

"An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]

"Disease-associated substitutions in the filamin B actin binding domain confer enhanced actin binding affinity in the absence of major structural disturbance: Insights from the crystal structures of filamin B actin binding domains."
J. Mol. Biol. 390:1030-1047(2009) [PubMed] [Europe PMC] [Abstract]

"Solution structure of the 9th through 24th filamin domains from human filamin-B."
Submitted (FEB-2009) to the PDB data bank

"Mutations in the gene encoding filamin B disrupt vertebral segmentation, joint formation and skeletogenesis."
Nat. Genet. 36:405-410(2004) [PubMed] [Europe PMC] [Abstract]

"Solution structure of filamin domains from human filamin-B."
Submitted (AUG-2007) to the PDB data bank

"Mutations in FLNB cause boomerang dysplasia."
J. Med. Genet. 42:E43-E43(2005) [PubMed] [Europe PMC] [Abstract]

"The consensus coding sequences of human breast and colorectal cancers."
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

"A molecular and clinical study of Larsen syndrome caused by mutations in FLNB."
J. Med. Genet. 44:89-98(2007) [PubMed] [Europe PMC] [Abstract]