Ring Finger Protein 55 (RNF55)

CBL; C-CBL; CBL2; Cas-Br-M(Murine)Ecotropic Retroviral Transforming Sequence; Casitas B-lineage Lymphoma; Proto-oncogene c-Cbl; Signal transduction protein CBL

SPN	R857
HGNC	1541
MGI	88279
PubMed	21422499
RGD	1561386
UniProt	P22681
Wiki	RNF55

The virus used in the experiment was a retrovirus known as Cas-Br-M, and was found to have excised approximately a third of the original c-Cbl gene from mice it was injected into. Sequencing revealed that the portion carried by the retrovirus encoded a tyrosine kinase binding domain, and that this was the oncogenic form as retroviruses carrying full-length c-Cbl did not induce tumour formation. The resultant transformed retrovirus was found to consistently induce a type of pre-B lymphoma, known as Casitas B-lineage lymphoma, in infected mice.

This domain structure and the tyrosine and serine-rich content of the protein product is typical of an "adaptor molecule" used in cell signalling pathways.

Reference

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