Eukaryotic Translation Elongation Factor 1 Alpha 1 (EEF1a1)

CCS-3; CCS3; EEF-1; EEF1A; EF-Tu; EF1A; FLJ25721; GRAF-1EF; LENG7; PTI1; eEF1A-1; Leukocyte Receptor Cluster(LRC)Member 7; Elongation factor Tu

SPN	R783
HGNC	3189
MGI	1096881
PubMed	22095224
RGD	67387
UniProt	P68104
Wiki	EEF1A1

Elongation factor 1-alpha 1 is an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of aminoacyl tRNAs to the ribosome. This isoform (alpha 1) is expressed in brain, placenta, lung, liver, kidney, and pancreas, and the other isoform (alpha 2) is expressed in brain, heart and skeletal muscle. This isoform is identified as an autoantigen in 66% of patients with Felty syndrome. This gene has been found to have multiple copies on many chromosomes, some of which, if not all, represent different pseudogenes.EF1-alpha showed strong nuclear staining and diffuse cytoplasmic staining in human foreskin fibroblasts. In contrast, EF1-beta, -gamma, and -delta showed a perinuclear distribution and colocalized with an endoplasmic reticulum resident protein.

Reference

"The primary structure of the alpha subunit of human elongation factor 1. Structural aspects of guanine-nucleotide-binding sites."
Eur. J. Biochem. 155:167-171(1986) [PubMed] [Europe PMC] [Abstract]

"Isolation and characterization of the human chromosomal gene for polypeptide chain elongation factor-1 alpha."
J. Biol. Chem. 264:5791-5798(1989) [PubMed] [Europe PMC] [Abstract]

"Retropseudogenes constitute the major part of the human elongation factor 1 alpha gene family."
Nucleic Acids Res. 18:1513-1516(1990) [PubMed] [Europe PMC] [Abstract]

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

"Structure of the amino-terminal end of mammalian elongation factor Tu."
Nucleic Acids Res. 14:2409-2409(1986) [PubMed] [Europe PMC] [Abstract]