Eukaryotic Translation Elongation Factor 1 Epsilon 1 (EEF1e1)

P18; AIMP3; Aminoacyl tRNA Synthetase Complex-Interacting Multifunctional Protein 3; Elongation factor p18; Multisynthase complex auxiliary component p18

SPN	R780
HGNC	3212
MGI	1913393
PubMed	24104880
RGD	1311056
UniProt	O43324
Wiki	EEF1E1

EEF1e1 encodes a multifunctional protein that localizes both in the cytoplasm and in the nucleus. In the cytoplasm, the encoded protein is an auxiliary component of the macromolecular aminoacyl-tRNA synthase complex. However, its mouse homolog has been shown to translocate to the nucleus in response to DNA damage and plays a positive role in ATM/ATR-mediated p53 activation. Alternative splicing results in multiple transcript variants.ATM activity was dependent on the level of p18, suggesting that p18 is required for activation of ATM. RT-PCR showed that p18 expression was low in several different human cancer cell lines and tissues. These results, as well as findings in p18 mutant mice, suggested that p18 is a haploinsufficient tumor suppressor and a key factor for ATM/ATR-mediated p53 activation.

Reference

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, Submitted (DEC-2008) to UniProtKB

"The haploinsufficient tumor suppressor p18 upregulates p53 via interactions with ATM/ATR."
Cell 120:209-221(2005) [PubMed] [Europe PMC] [Abstract]

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"Determination of three-dimensional structure and residues of the novel tumor suppressor AIMP3/p18 required for the interaction with ATM."
J. Biol. Chem. 283:14032-14040(2008) [PubMed] [Europe PMC] [Abstract]