Eukaryotic Translation Termination Factor 1 (ETF1)

SUP45L1; ERF1; ERF; eRF1, TB3-1; RF1; Sup45(Yeast Omnipotent Suppressor 45)Homolog-Like 1; Polypeptide Chain Release Factor 1; Protein Cl1

SPN	R776
HGNC	3477
MGI	2385071
RGD	1305712
UniProt	P62495

Termination of protein biosynthesis and release of the nascent polypeptide chain are signaled by the presence of an in-frame stop codon at the aminoacyl site of the ribosome. A class 1 RF recognizes the stop codon and promotes the hydrolysis of the ester bond linking the polypeptide chain with the peptidyl site tRNA, a reaction catalyzed at the peptidyl transferase center of the ribosome. Class 2 RFs, which are not codon specific and do not recognize codons, stimulate class 1 RF activity and confer GTP dependency upon the process. In prokaryotes, both class 1 RFs, RF1 and RF2, recognize UAA; however, UAG and UGA are decoded specifically by RF1 and RF2, respectively. In eukaryotes, eRF1, or ETF1, the functional counterpart of RF1 and RF2, functions as an omnipotent RF, decoding all 3 stop codons .

Reference

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Gene 110:239-243(1992) [PubMed] [Europe PMC] [Abstract]

"A highly conserved eukaryotic protein family possessing properties of polypeptide chain release factor."
Nature 372:701-703(1994) [PubMed] [Europe PMC] [Abstract]

"The catalytic subunit of protein phosphatase 2A associates with the translation termination factor eRF1."
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